American Journal of Biomedical Engineering

American Journal of Biomedical Engineering provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes.

Markus O. Heller

Editorial Board Member of American Journal of Biomedical Engineering

Research Scientist, Julius Wolff Institute, Charité C Universitatsmedizin Berlin, Germany

Research Areas

Biomechanics of The Human Lower Extremity; Physiological Musculoskeletal Loading Conditions Within The Long Bones; Joint Mechanics of The Native and Replaced Hip and Knee Joints; Fracture Healing and Regeneration; Gait Analysis; Functional Joint Morpholog


2002Ph.DInstitute of Orthopaedic Research and Biomechanics at the University of Ulm, Germany


Since 2008Leader of the Musculoskeletal Biomechanics group at the Julius Wolff Institute (Director: Prof. Dr. Duda)
Since 2005Leader of the Musculoskeletal Biomechanics group at the Research Laboratories of the Center for Musculoskeletal Surgery
1999-2004Research fellow at the Research Laboratories (Director: Prof. Dr. G.N. Duda) of the Center for Musculoskeletal Surgery at the Charité-Universitatsmedizin Berlin, Germany (Director: Prof. Dr. med. N.P. Haas)
1997-1999Research fellow at the Institute of Orthopaedic Research and Biomechanics at the University of Ulm, Germany (Prof. Dr. L. Claes)
1994-1995Research assistant at the Institute for Applied Computer Sciences (ICA) at the University of Stuttgart
1992-1993Internship at the Deutsche Airbus GmbH, Speyer, Germany

Academic Achievement

New Investigator Recognition Award of the Orthopaedic Research Society (ORS) (Basic Science Award) Heller, Bergmann, Deuretzbacher, Haas, Claes, Duda:Hip contact and proximal femoral loading increases with anteversion: Measurements and simulations in 4 pa
Clinical Biomechanics Award of the European Society of Biomechanics (ESB) Heller, Bergmann, Deuretzbacher, Claes, Haas, Duda:Influence of femoral anteversion on proximal femoral loading: measurement and simulation in 4 patients(2000)
Gisela Sturm Award of the Schulthess Klinik, Zürich Heller, Bergmann, Deuretzbacher, Dürselen, Pohl, Claes, Haas, Duda:Musculo-skeletal loading conditions at the hip during walking and stair climbing(2001)
S. M. Perren Award of the European Society of Biomechanics (ESB) Kassi, Heller, Stockle, Perka, Duda: Muscle activity is essential for preclinical assessment of primary stability in THA. (2002)


German Society for Biomechanics (DGfB)-serving on the council (treasurer)
Orthopaedic Research Society (ORS)
International Society for Computer Assisted Orthopaedic Surgery (CAOS-International)
Institute of Electrical and Electronics Engineers (IEEE)

Publications: Journals

[1]  Trepczynski A., Kutzner I., Kornaropoulos E., Taylor W.R., Duda G.N., Bergmann G., Heller M.O.Patello-femoral joint contact forces during activities with high knee flexion.J Orthop Res [2011]; accepted.
[2]  Konig C., Matziolis G., Sharenkov A., Taylor W.R., Perka C., Duda G.N., Heller M.O.Collateral ligament length change patterns after joint line elevation may notexplain midflexion instability following TKA.Med Eng Phys [2011]; doi: 10.1016/j.medengphy.2011.06.008
[3]  Heller M.O., Mehta M., Taylor W.R., Kim D.-Y., Speirs A., Duda G.N., Perka C. Influence of prosthesis design and implantation technique on implant stresses after cementless revision THR. J Orthop Surg Res [2011]; 6(1):20
[4]  Heller M.O., Kratzenstein S., Ehrig R.M., Wassilew G., Duda G.N., Taylor W.R.The weighted Optimal Common Shape Technique improves identification of the hip joint centre of rotation in vivo. J Orthop Res [2011];29(10):1470-5
[5]  Ehrig R.M, Heller M.O., Kratzenstein S., Duda G.N., Trepcynski A., Taylor W.R.The SCoRE residual: A quality index to assess the accuracy of joint estimations.J Biomech [2011]; 44(7): 1400-4
[6]  Taylor W.R., Popplau B.M., Konig. C, Ehrig R.M., Zachow S., Duda G.N., Heller M.O.The medial-lateral force distribution in the ovine stifle joint during walking.J Orthop Res [2011]; 29(4): 567-71
[7]  Konig C., Sharenkov A., Matziolis G., Taylor W.R., Perka C., Duda G.N., Heller M.O.Joint line elevation in revision TKA leads to increased patellofemoral contact forces.J Orthop Res [2010]; 28(1): 1-5. 3.0
[8]  Kornaropoulos E.I., Taylor W.R., Duda G.N., Ehrig R.M., Matziolis G., Müller M., Wassilew G., Asbach P., Perka C., Heller M.O.Frontal plane alignment: An imageless method to predict the mechanical femoral-tibial angle (mFTA) based on functional determination of joint centers and axes.Gait Posture [2010]; 31(2): 204-8.
[9]  Taylor W.R., Kornaropoulos E.I., Duda G.N., Kratzenstein S., Ehrig R.M., Arampatzis A., Heller M.O.Repeatability and reproducibility of OSSCA, a functional approach for assessing the kinematics of the lower limb.Gait Posture [2010]; 32(2): 231-6.
[10]  Goudakos I.G., Konig C., Schottle P.B., Taylor W.R., Hoffmann J.E., Popplau B., Singh N.B., Duda G.N., Heller MO.Regulation of the patellofemoral contact area: an essential mechanism in patellofemoral joint mechanics?J Biomech [2010]; 43(16): 3237-3239.
[11]  Goudakos I.G., Konig C., Schottle P.B., Taylor W.R., Singh N.B., Roberts I., Streitparth F., Duda G.N., Heller MO. Stair climbing results in more challenging patellofemoral contact mechanics and kinematics than walking at early knee flexion under physiological-like quadriceps loading.J Biomech [2009]; 42(15): 2590-6.
[12]  Schottle P., Goudakos I., Rosenstiel N., Hoffmann J-E, Taylor W.R., Duda G.N., Heller M.O.A comparison of techniques for fixation of the quadriceps muscle-tendon complex for in vitro biomechanical testing of the knee joint in sheep.Med Eng Phys [2009]; 31(1): 69-75.
[13]  Heller M.O., Konig C., Graichen H., Hinterwimmer S., Ehrig R. M., Duda, G. N., Taylor W. R.A new model to predict in vivo human knee kinematics under physiological-like muscle activation.J Biomech [2007]; 40(S1): 45-53.
[14]  Heller M.O., Schroder J.H., Matziolis G., Sharenkov A., Taylor W.R., Perka C., Duda G.N.Muskuloskeletale Belastungsanalysen. Biomechanische Erklarung klinischer Resultate-und mehrOrthopade [2007]; 36(3): 188-94.
[15]  Ehrig R.M., Taylor W.R., Duda G.N., Heller M.O.A survey of formal methods for determining functional joint axes.J Biomech [2007]; 40(10): 2150-7.
[16]  Ehrig R.M., Taylor W.R., Duda G.N., Heller M.O.A survey of formal methods for determining the centre of rotation of ball joints.J Biomech [2006]; 39(15): 2798-809.
[17]  Taylor W.R., Ehrig R.M., Duda G.N., Schell H., Klein P., Heller M.O.On the influence of soft tissue coverage in the determination of bone kinematics using skin markers.J Orthop Res [2005]; 23(4): 726-34.
[18]  Heller M.O., Duda G.N., Ehrig R.M., Schell H., Seebeck P., Taylor W.R.Muskuloskeletale Belastungen im Schafshinterlauf:Mechanische Rahmenbedingungen der Heilung.Materialwissenschaft und Werkstofftechnik [2005]; 36(12): 775-80.
[19]  Heller M.O., Bergmann G., Kassi J.-P., Claes L., Haas N.P., Duda G.N.Determination of muscle loading at the hip joint for use in pre-clinical testing.J Biomech [2005]; 38(5): 1155-63.
[20]  Heller M.O., Kassi J.P., Perka C., Duda G.N.Cementless stem fixation and primary stability under physiological-like loads in vitro.Biomed Tech [2005]; 50(12): 394-9.
[21]  Heller M.O., Taylor W.R., Perka C., Duda G.N.The influence of alignment on the musculo-skeletal loading conditions at the knee.Langenbecks Arch Surg [2003]; (388): 291-7.
[22]  Heller M.O., Bergmann G., Deuretzbacher G., Claes L., Haas N.P., Duda G.N.ESB Clinical Biomechanics Award: Influence of femoral anteversion on proximal femoral loading: measurement and simulation in four patients.Clin Biomech [2001]; 16(8): 644-9.
[23]  Heller M.O., Bergmann G., Deuretzbacher G., Dürselen L., Pohl M., Claes L., Haas N.P., Duda G.N.Musculo-skeletal loading conditions at the hip during walking and stair climbing.J Biomech [2001]; 34(7): 883-93.
[24]  Hamacher D., Singh N.B., Van Dieen J.H., Heller M.O., Taylor W.R.Kinematic measures for assessing gait stability in elderly individuals: A systematic review. Journal of the Royal Society Interface [2011] accepted
[25]  Wassilew G.I., Heller M., Wenzl M., Perka C., Hasart O.Validation of a CT image based software for three-dimensional measurement of acetabular cup orientation. Technol Health Care (in press).
[26]  Witt F., Schell H, Heller M.O., Duda G.N.Die Bedeutung der Biomechanik bei der physiologischen Frakturheilung.Osteologie [2011]; 20(1): 17-22.
[27]  Singh N.B., Arampatzis A., Duda G.N., Heller M.O., Taylor W.R. Effect of fatigue on force fluctuations in knee extensors in young adults.Philos Transact A Math Phys Eng Sci [2010]; 368(1920):2783-98.
[28]  Bergmann G., Graichen F., Rohlmann A., Bender A., Heinlein B., Duda G.N., Heller M.O., Morlock M.M.Realistic loads for testing hip implants.Bio-Medical Materials and Engineering [2010];20(2):65-75.
[29]  Mihalko WM, Saleh KJ, Heller M.O., Mollard B, Konig C, Kammerzell S.Femoral neck cut level affects positioning of modular short-stem implant.Orthopedics [2009];32(10 Suppl):18-21.
[30]  Speirs A.D., Heller M.O., Taylor W.R., Duda G.N., Perka C.Influence of changes in stem positioning on femoral loading afterTHR using a short-stemmed hip implant.Clin Biomech [2007]; 22(4): 431-9.
[31]  Speirs A.D., Heller M.O., Duda G.N., Taylor W.R.Physiologically based boundary conditions in finite element modelling.J Biomech [2007]; 40(10): 2318-23.
[32]  Epari D.R., Taylor W.R., Heller M.O., Duda G.N.Mechanical conditions in the initial phase of bone healing.Clin Biomech [2006]; 21(6): 646-55.
[33]  Taylor W.R., Ehrig R.M., Heller M.O., Schell H., Seebeck P., Duda G.N.Tibio-femoral joint contact forces in sheep.J Biomech [2006]; 39(5): 791-8.
[34]  Duda G., Maldonado Z., Klein P., Heller M., Burns J., Bail H.On the influence of mechanical conditions in osteochondral defect healing.J Biomech [2005]; 38(4): 843-51.
[35]  Kassi J.-P., Heller M., Stoeckle U., Perka C., Duda G.N.SM Perren Award of the ESB: Stair climbing is more critical than walking in pre-clinical assessment of primary stability in cementless THA in vitro.J Biomech [2005]; 38(5): 1143-54.
[36]  Perka C., Heller M., Wilke K., Taylor W.R., Haas N.P., Zippel H., Duda G.N.Surgical approach influences periprosthetic femoral bone density.Clin Orthop Related Res [2005]; 43(432): 153-9.
[37]  Klein P., Opitz M., Schell H., Taylor W.R., Heller M.O., Kassi J.-P., Kandziora F., Duda G.N.Comparison of unreamed nailing and external fixation of tibial diastases--mechanical conditions during healing and biological outcome.J Orthop Res [2004]; 22(5): 1072-8.
[38]  Taylor W.R., Heller M.O., Bergmann G., Duda G.N.Tibio-femoral loading during human gait and stair-climbing.J Orthop Res [2004]; 22(3): 625-32.
[39]  Schroder J., Heller M.O., Matziolis G., Taylor W.R., Sharenkov A., Wulsch P., Duda G.N., Perka C.Belastungsoptimierte Operationsplanung von Hüftendoprothesen.Z Orthop Ihre Grenzgeb [2004]; 142(5): 515-6.
[40]  Duda G.N., Mandruzzato F., Heller M., Schütz M., Claes L., Haas N.P.Mechanische Grenzindikationen der unaufgebohrten Marknagelung.Unfallchirurg [2003]; 106(8): 683-9. 0.5
[41]  Kleemann R.U., Heller M.O., Stoeckle U., Taylor W.R., Duda G.N.THA loading arising from increased femoral anteversion and offset may lead to critical cement stresses.J Orthop Res [2003]; 21(5): 767-74.
[42]  Klein P., Schell H., Streitparth F., Heller M., Kassi J.-P., Kandziora F., Bragulla H., Haas N.P., Duda G.N.The initial phase of fracture healing is specifically sensitive to mechanical conditions.J Orthop Res [2003]; 21(4): 662-9.
[43]  Maldonado Z.M., Seebeck J., Heller M.O.W., Brandt D., Hepp P., Lill H., Duda G.N.Straining of the intact and fractured proximal humerus under physiological-like loading.J Biomech [2003]; 36(12): 1865-73.
[44]  Duda G.N., Mandruzzato F., Heller M., Kassi J.-P., Khodadadyan C., Haas N.P.Mechanical conditions in the internal stabilization of proximal tibial defects.Clin Biomech [2002]; 17(1): 64-72.
[45]  Bergmann G., Deuretzbacher G., Heller M., Graichen F., Rohlmann A., Strauss J., Duda G.N.Hip contact forces and gait patterns from routine activities.J Biomech [2001]; 34(7): 859-71.
[46]  Duda, G.N., Mandruzzato F., Heller M., Goldhahn J., Moser R., Hehli M., Claes L., Haas N.P.Mechanical boundary conditions of fracture healing: borderline indicationsin the treatment of unreamed tibial nailing.J Biomech [2001]; 34(5): 639-50.
[47]  Kassi J.P., Hoffmann J.E., Heller M., Raschke M., Duda G.N.Bewertung der Stabilitat von Frakturfixationssystemen: Mechanische Vorrichtung zur Untersuchung der 3-D-Steifigkeit in vitro.Biomed Tech [2001]; 46(9): 247-52.
[48]  Duda G.N., Heller M., Albinger J., Schulz O., Schneider E., Claes L.Influence of muscle forces on femoral strain distribution.J Biomech [2001]; 31(9): 841-6.

Publications: Books/Book Chapters

[1]  Duda G.N., Konig C., Bergmann G., Tohtz S., Perka C., Heller M.O.Biomechanics of the Artificial Berry, (Hrsg.): The Hip. to appear.
[2]  Duda G.N., Heller M.O., Pfitzner T., Taylor W.R., Konig C., Bergmann G. Biomechanik des D.C. Wirtz (Hrsg): AE-Manual der Endoprothetik. Knie.1st Edition 2011, DOI 10.1007/978-3-642-12889-9_2 (13 Seiten)
[3]  Heller M.O., Duda G.N.Die Bedeutung der Gelenkgeometrie für die muskuloskelettalen Belastungen nach C. Perka und H. Zippel (Hrsg.): Trends und Kontroversenin der Endoprothetik des Hüftgelenkes.Einhorn-Presse Verlag, Reinbek, 2002:12-21.
[4]  Duda G., Heller M.Bedeutung der komplexen muskulo-skelettalen Beanspruchung für die Hü C. Perka und H. Zippel (Hrsg.): Pfannenrevisionseingriffe nach Hüft-TEP.Einhorn-Presse Verlag, Reinbek, 2000: 17-19.