American Journal of Biochemistry

American Journal of Biochemistry is a peer-reviewed international journal dedicated to provide an active forum to the global scientific community for publishing and disseminating high quality research work in the field of biochemistry.

Nuska Tschammer

Editorial Board Member of American Journal of Biochemistry

Doctoral, University of Erlangen/Nurmberg, Department of Chemistry and Pharmacy, Germany

Research Areas

Medicinal Chemistry, Molecular Biology, Chemical Biology

Education

2004-2007Ph.DBiomolecular Sciences, Prof. Annette Khaled, Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, USA
1999-2002M.ScChemical Technology/Chemistry of Polymers, Prof. Crtomir Stropnik, Faculty of Chemistry and Chemical Technology, University of Maribor, Slovenia
1993-1998BachelorBiology and Chemistry, Faculty of Education, University of Maribor, Slovenia

Experience

2011-presentSenior Researcher (Akademische Rätin auf Zeit), Chair of Medicinal Chemistry, Department of Chemistry and Pharmacy, University of Erlangen, Nurnberg, Germany
2003-2004Technical Assistant, Prof. Annette Khaled, Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, USA
2008-2010Postdoc/Research Assistant, Prof. Peter Gmeiner, Chair of Medicinal Chemistry, Department of Chemistry and Pharmacy, University of Erlangen, Nurnber, Germany
2003-2007Research Assistant/Ph.D. student, Prof. Annette Khaled, Biomolecular Science Center, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, USA
2002-2003Research Assistant, Prof. Michael Hallek, Klinikum Grosshadern, Ludwig Maximilians University of München, Germany
2000-2002Research and Teaching Assistant, Prof. Vojko Musil, Faculty of Economy and Management, University of Maribor, Slovenia
1999-2000Teaching Assistant, Faculty of Education, University of Maribor, Slovenia
1999Research Assistant (Project Work), Department of Biology, Phillips-University of Marburg, Germany
1998Summer Research, Prof. Ronn Altig, Department of Biology, Mississippi State University, Mississippi State, USA
1988-1999Teacher of Biology and Chemistry, Elementary School Sempeter, Slovenia

Academic Achievement

2010 Travel Award: Förderung der Teilnahme an wissenschaftlichen Tagungen, University of Erlangen-Nürnberg, Germany (for the participation and presentation on STS Meeting 2010, Weimar, Germany)
2009 Travel Award: Förderung der Teilnahme an wissenschaftlichen Tagungen, University of Erlangen-Nürnberg, Germany (for the participation and presentation on STS Meeting 2009, Weimar, Germany)
2008 Travel Award: Förderung der Teilnahme an wissenschaftlichen Tagungen, University of Erlangen-Nürnberg, Germany (for the participation and slide presentation on Neuroscience Meeting 2008, Washington, DC)
2006 Travel Award of the American Society for Cell Biology, San Diego, USA
2001 The Award for Oral Presentation, 9th Conference on materials and technology, Portoroz, Slovenia
2001 The Award for Poster Presentation 13th IGWT Symposium, 2-8 September 2001, Maribor, Slovenia

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  KRALJ, A., WETZEL A., MAHMOUDIAN, S., STAMMINGER, T., TSCHAMMER, N., HEINRICH, M., Identification of novel allosteric modulators for the G-protein coupled US28 receptor of human cytomegalovirus. Bioorg. Med. Chem. Lett., 2011, In Press, doi>10.1016/j.bmcl.2011.06.120.
[2]  KOSCHATZKY, S., TSCHAMMER, N., GMEINER, P., Cross-receptor interactions between dopamine D2L and neurotensin NTS1 receptors modulate binding affinities of dopaminergics. ACS Chem. Neurosci., 2011, 2, 308-316, doi>10.1021/cn20002y.
[3]  EINSIEDEL, J., HELD, C., MAUD, H., PLOMER, M., TSCHAMMER, N., HÜBNER, H., GMEINER, P., Discovery of highly potent and NTS2 selective neurotensin mimetics. J. Med. Chem., 2011, 54, 2915-2923, doi>10.1021/jm200006c.
[4]  TSCHAMMER, N., ELSNER, J., GÖTZ, A., EHRLICH, K., SCHUSTER, S., RUBERG, M., KÜHHORN, J., THOMPSON, D., WHISTLER, J., HÜBNER, H.,GMEINER, P., Highly potent 5-aminotetrahydropyrazolopyridines: Enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions, J. Med. Chem., 2011, 54, 2477-2491, doi>10.1021/jm101639t.
[5]  LÖBER, S., HÜBNER, H., TSCHAMMER, N., GMEINER, P., Recent advances on the search of D3 and D4 selective drugs: probes, models and candidates, Trends in Pharm. Sci., 2011, 32 (3), 148-157, doi:10.1016/j.tips.2010.12.003.
[6]  TSCHAMMER, N., BOLLINGER, S., KENAKIN, T., GMEINER, P., Histidine 6.55 is a major determinant of ligand biased signaling in dopamine D2L receptor. Mol.Pharmacol. 2011, 79 (3), 575-585, doi:10.1124/mol.110.068106.
[7]  KITTIPATARIN, C., TSCHAMMER, N., KHALED, A.R., The interaction of LCK and the CD4 co-receptor alters the dose response of T-cells to interleukin-7. Immunol. Lett., 2010, 131, 170-181. doi: 10.1016/j.imlet.2010.04.007.
[8]  TSCHAMMER, N., DÖRFLER, M., HÜBNER, H., GMEINER, P., Engineering a GPCR-Ligand Pair that Simulates the Activation of D2L by Dopamine. ACS Chemical Neuroscience, 2010, 1, 25-35, doi>10.1021/cn900001b.
[9]  EHRLICH, K., GÖTZ, A., BOLLINGER, S., TSCHAMMER, N., HÄRTERICH, S., HÜBNER, H., GMEINER, P., Dopamine D2, D3 and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. J. Med. Chem., 2009, 52(15): 4923-4935. doi>10.1021/jm900690y.
[10]  LÖBER, S., TSCHAMMER, N., HÜBNER, H., MELIS, M.R., ARGIOLAS, A., GMEINER, P., The azulene framework as a novel bioisostere: Design of potent dopamine D4 receptor ligands inducing penile erection. ChemMedChem, 2009, 4(3): 325-328. doi>10.1002/cmdc.200800395.
[11]  DÖRFLER, M., TSCHAMMER, N., HAMPERL, K., HÜBNER, H., GMEINER, P., Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosters: Synthesis, bioactivity, and mutagenesis studies. J. Med. Chem., 2008, 51(21): 6829-6838. doi>10.1021/jm800895v.
[12]  KAUR, N., DELCROS, J., CHEHTAN, M., TSCHAMMER, N., KHALED, A.R., PHANSTIEL, O., 4th, A comparison of chlorambucil-and xylene-containing polyamines leads to improved ligands for accessing the polyamine transporter. J. Med. Chem., 2008, 51(5): 1393-1401. doi>10.1021/jm070794t.
[13]  KHALED, A.R., TSCHAMMER, N., ZHANG, G., SELBY, T.A., Structural transitions that regulate the apoptotic activity of BAX are dependent on its C-terminal alpha-9 helix. Cell Death, Self-Renewal and Cell Cycle in Development (84.1-84.13). J.Immunol., 2007, 178:S117.
[14]  TSCHAMMER, N., G., SELBY, T.A., KHALED, A.R., The membrane-binding activity of the apoptotic Protein, BAX, is regulated through novel intramolecular interactions, Cytokine, 2007, 39(1): 42-43. doi>10.1016/j.cyto.2007.07.159.
[15]  GUO, S., TSCHAMMER, N., MOHAMMED, S., GUO, P., Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA. Hum. Gene Ther., 2005, 16(9): 1097-1109. doi>10.1089/hum.2005.16.1097.
[16]  TSCHAMMER, N., GUO, P.X., KHALED, A.R., Use of the bacteriophage phi29 packing RNA as nanovehicle for targeted delivery of therapeutic RNAs to CD4+ T-cells, FASEB J., 2005, 19(5): A1405-A1405.
[17]  VOGRIN, N., STROPNIK, Č., MUSIL, V. BRUMEN, M., The wet phase separation: the effect of cast solution thickness on the appearance of macrovoids in the membrane forming ternary cellulose acetate/acetone/water system. J. Membr.Sci.., 2002, 207, 139-141. doi>10.1016/S0376-7388(02)00119-9.
[18]  SURGET-GROBA, Y., HEULIN, B., GHIELMI, S., GUILLAUME, C.-P., VOGRIN, N., Phylogeography and conservation of the populations of Zootoca vivipara carniolica, Biol.Consr., 2002, 106(3): 365-372. doi>10.1016/S0006-3207(01)00263-4.
[19]  HEULIN, B., VOGRIN, N., GHIELMI, S., SURGET-GROBA, Y.,GUILLAUME, C.-P., Variation in eggshell characteristics and in intrauterine egg retention between two oviparous clades of the lizard Lacerta vivipara: Insight into the oviparity-viviparity continuum in squamates, J. of Morph.2002, 252(3):255-262. doi>10.1002/jmor.1103.
[20]  SURGET-GROBA, Y., HEULIN, B., GUILLAUME, C.-P., THORPE, R. S., KUPRIYANOVA, L., VOGRIN, N., MASLAK, R., MAZZOTTI, S., VENCZEL, M., GHIRA, I., ODIERNA, G., LEONTYEVA, O., MONNEY, J.C., SMITH, N., Intraspecific phylogeography of Lacerta vivipara and the evolution of viviparity. Mol. Phylogenet.Evol., 2001, 18(3), 449-459. doi>10.1006/mpev.2000.0896.
[21]  ODIERNA, G., HEULIN, B., GUILLAUME, C.-P., VOGRIN, N., APREA, G., CAPRIGLIONE, T., SURGET-GROBA, Y., KUPRIYANOVA, L., Evolutionary and biogeographical implications of the karyological variations in the oviparous and viviparous forms of the lizard Lacerta (Zootoca) vivipara. Ecography (Cph.), 2001, 24, 332-340.
[22]  HEULIN, B., GUILLAUME, C.-P., VOGRIN, N., SURGET-GROBA, Y., TADIČ, Z., Further evidence of the existence of oviparous populations of Lacerta (Zootoca) vivipara in the NW of the Balkan Peninsula. C r. Acad. sci., Sér. 3, Sci. vie., 2000, 323, 461-468. doi>10.1016/S0764-4469(00)00155-4
[23]  THOMAS, R. B., VOGRIN, N., ALTIG, R., Sexual and seasonal differences in behaviour of Trachemys scripta : (Testudines: Emydidae). J. Herpetol., 1999, 33(3), 511-515. doi>10.1643/0045-8511(2002)002[0456:CMSIAL]2.0.CO;2.