Clinical Medicine and Diagnostics

Clinical Medicine and Diagnostics is a peer-reviewed journal publishing papers of significance in all areas of medical sciences. Articles include original research papers, reviews and short research communications. Submissions of basic and clinical research are both considered.


Andrew Andonopoulos

Editorial Board Member of Clinical Medicine and Diagnostics

Professor, Patras University School of Medicine, Dept of Medicine, Division of Rheumatology, Greece

Research Areas

Pathogenesis and Treatment of Autoimmune and Inflammatory Rheumatic Diseases, Osteoimmunology

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Andonopoulos AP, Fernadez-Madrid F: Successfully treated splenic abscess in a systemic lupus erythematosus patient. A case report and review of the literature. Clin Exp Rheumatol 4: 269-271, 1986.
[2]  Andonopoulos AP, Asimakopoulos G, Anastasiou E, Bassaris HP: Brucella arthritis. Scand J Rheumatol 15: 377-380, 1986.
[3]  Andonopoulos AP, Asimakopoulos G, Mallioris C, Karatza C, Scopa C: The diagnostic value of gastrocnemius muscle biopsy in sarcoidosis presenting with erythema nodosum and hilar adenopathy. Clin Rheumatol 6: 192-196, 1987.
[4]  Andonopoulos AP, Galanopoulou V, Drosos AA, Moutsopoulos HM: Rheuma-toid arthritis in Greece. Manifestations in different age groups. Rheumatol Int 7: 101-105, 1987.
[5]  Andonopoulos AP, Drosos AA, Skopouli FN, Acritidis NC, Moutsopoulos HM: Secondary Sjogren's syndrome in rheumatoid arthritis. J Rheumatol 14: 1098-1103, 1987.
[6]  Drosos AA, Andonopoulos AP, Costopoulos JS, Papadimitriou CS, Moutso-poulos HM: Prevalence of primary Sjogren's syndrome in an elderly population. Br J Rheumatol 27: 123-127, 1988.
[7]  Drosos AA, Vliet-Dascalopoulou E, Andonopoulos AP, Galanopoulou V, Sko-pouli FN, Moutsopoulos HM: Nandrolone decanoate (Deca-Durabolin) in primary Sjogren's syndrome: A double blind pilot study. Clin Exp Rheumatol 6: 53-57, 1988.
[8]  Papasteriades CA, Skopouli FN, Drosos AA, Andonopoulos AP, Moutsopoulos HM: HLA alloantigen associations in Greek patients with Sjogren's syndrome. J Autoimmunity 1: 85-90, 1988.
[9]  Andonopoulos AP, Karadanas AH, Drosos AA, Acritidis NC, Katsiotis P, Moutsopoulos HM: Evaluation of mediastinal lymph-nodes by computed tomography in primary Sjogren's syndrome. A controlled study. J Comp Ass Tom 12(2): 199-201, 1988.
[10]  Andonopoulos AP, Constantopoulos SH, Drosos AA, Moutsopoulos HM: Pulmonary function of non-smoking patients with rheumatoid arthritis in the presence and absence of sencondary Sjogren's syndrome. A controlled study. Respiration 53: 251-258, 1988.
[11]  Andonopoulos AP, Constantopoulos SH, Galanopoulou V, Drosos AA, Acritidis NC, Moutsopoulos HM: Pulmonary function of non-smoking patients with systemic lupus erythematosus; A controlled study. CHEST 94: 312-315, 1988.
[12]  Acritidis NC, Andonopoulos AP, Galanopoulou V, Drosos AA, Constan-to-poulos SH, Moutsopoulos HM: Pulmonary function of non-smoking patients with giant cell arteritis and/or polymyalgia rheumatica. A controlled study. Clin. Rheumatol. 7: 231-236, 1988.
[13]  Drosos AA, Andonopoulos AP, Costopoulos JS, Papadimitriou CS, Stavropoulos ED, Moutsopoulos HM: Sjogren's syndrome in Progressive Systemic Sclerosis. J Rheumatol 15: 965-968, 1988.
[14]  Moutsopoulos HM, Andonopoulos AP: Sjogren's syndrome. A human model of autoimmunity and malignancy (Editorial). Br J Rheumatol 27: 253-257, 1988
[15]  Drosos AA, Andonopoulos AP, Skopouli FN: Keratoconjunctivitis sicca in rheumatoid arthritis. Clin Rheumatol 7: 547-548, 1988.
[16]  Skopouli FN, Andonopoulos AP, Moutsopoulos HM: Clinical implications of the presence of anti-Ro (SSA) antibodies in patients with rheumatoid arthritis. J Autoimmunity 3:381-388, 1988.
[17]  Siamopoulou-Mavridou A, Drosos AA, Andonopoulos AP: Sjogren's syndrome in childhood. Report of two cases. Eur J Pediatrics 148:523-524, 1989.
[18]  Andonopoulos AP, Lagos G, Drosos AA, Moutsopoulos HM: Neurologic involvement in primary Sjogren's syndrome. A preliminary report. J Autoimmunity 2:485-488, 1989.
[19]  Andonopoulos AP, Drosos AA, Skopouli FN, Moutsopoulos HM: Sjogren's syndrome in rheumatoid arthritis and progressive systemic sclerosis. A comparative study. Clin Exp Rheumatol 7:203-205, 1989.
[20]  Drosos AA, Andonopoulos AP, Lagos G, Angelopoulos NV, Moutsopoulos HM: Neuropsychiatric abnormalities in primary Sjogren's syndrome. Clin Exp Rheumatol 7:207-209, 1989.
[21]  Siamopoulou A, Mavridis AK, Vasakos S, Benecos P, Tzioufas AG, Ando-nopoulos AP: Sialochemistry in Juvenile Chronic Arthritis. Br J Rheumatol 28:383-385, 1989.
[22]  Andonopoulos AP, Lagos G, Drosos AA, Moutsopoulos HM: The spectrum of neurological involvement in Sjogren's syndrome. Br J Rheumatol 29:21-23, 1990.
[23]  Andonopoulos AP, Papasteriades CA, Drosos AA, Dimou GS, Moutsopoulos HM: HLA alloantigens in Greek patients with systemic lupus erythematosus. Clin Exp Rheumatol 8:47-50, 1990.
[24]  Andonopoulos AP, Skopouli FN, Dimou GS, Drosos AA, Moutsopoulos HM: Sjogren's syndrome in systemic lupus erythematosus. J Rheumatol 17: 201-204, 1990.
[25]  Drosos AA, Psychos D, Andonopoulos AP, Stefanaki-Nikou S, Tsianos EB, Moutsopoulos HM: Methotrexate therapy in rheumatoid arthritis. A two year prospective follow up. Clin Rheumatol 9:333-341, 1990.
[26]  Andonopoulos AP: Adult respiratory distress syndrome: an unrecognized pre-mortem event in patients with systemic lupus erythematosus. Br J Rheumatol 30:346-348, 1991.
[27]  Andonopoulos AP, Papathanasopoulos PG, Karatza C, Angelopoulos J, Papapetropoulos T: Sarcoidosis in a patient with myasthenia gravis. Case report and review of the literature. Clin Rheumatol 10:323-325, 1991.
[28]  Andonopoulos AP, Tzanakakis G, Christofidou M: Light salivary microscopy in the evaluation of xerostomia of the sicca syndrome. A preliminary report. J Rheumatol 19:1390-1392, 1992.
[29]  Andonopoulos AP, Tzanakakis G: Excessive fibrosis of supraclavicular lymph node granulomas in a patient with progressive systemic sclerosis. Rheumatol Int 12:255-257, 1993.
[30]  Andonopoulos AP, Gogos CA, Tzanakakis G: Subcutaneous edema: an "unrecognized" feature of acute polymyositis. Rheumatol Int 13:159-161, 1993.
[31]  Skoutelis A, Andonopoulos A, Panagiotopoulos E, Bassaris H: Non-tropical pyomyositis in adults: Report of four cases and literature review. Eur J Clin Micr Inf Dis 12:769-772, 1993.
[32]  Katevas P, Andonopoulos AP, Kourakli-Symeonidis A, Manopoulou E, Lafi T, Makri M, Zoumbos NC: Peripheral blood mononuclear cells from patients with rheumatoid arthritis suppress erythropoiesis in vitro via the production of tumor necrosis factor alpha. Eur J Haematol 53:26-39, 1994.
[33]  Andonopoulos AP, Terzis E. Tsibri E, Papasteriades CA, Papapetropoulos T: D-Penicillamine induced myasthenia gravis in rheumatoid arthritis: an unpredictable common occurence? Clin Rheumatol 13:586-588, 1994.
[34]  Skoutelis A, Andonopoulos A, Lazarou N, Bassiaris H: Antinuclear antibodies in visceral leishmaniasis. J Infection 29:357-359, 1994.
[35]  Andonopoulos AP, Yarmenitis SD, Dimopoulos PA: Dual energy X-ray absorptiometry in rheumatoid arthritis: Comparison between axial and appendicular skeleton findings. A preliminary report. Br J Gen Pract 49:111-112, 1995.
[36]  Andonopoulos AP, Naxakis S, Goumas P, Lygatsikas C: Sensorineural hearing disorders in systemic lupus erythematosus. A controlled study. Clin Exp Rheumatol 13:137-141, 1995.
[37]  Sfontouris H, Galanopoulos N, Kappou-Rigatou I, Spyropoulos C, Dandis P, Andonopoulos AP: Superior sagittal sinus thrombosis in a patient with Behcet's disease and the Mayer-Rokitansky-Kuster-Hauser syndrome. Clin Rheumatol 14:486-488, 1995.
[38]  Andonopoulos AP, Ballas C: Autonomic cardiovascular neuropathy in primary Sjogren's syndrome. Rheumatol Int 15:127-129, 1995.
[39]  Andonopoulos AP, Yarmenitis S, Sfontouris H, Siamplis D, Zervas C, Bounas A: Baker's cyst in rheumatoid arthritis. An ultrasonographic study with high resolution technique. Clin Exp Rheumatol 13:633-636, 1995.
[40]  Andonopoulos AP, Siambi V, Makri M, Christofidou M, Markou C, Vagenakis AG: Thyroid function and immune profile in rheumatoid arthritis. A controlled study. Clin Rheumatol 15:599-603, 1996.
[41]  Goritsas C, Repanti M, Papadaki E, Lazarou N, Andonopoulos AP: Intrahepatic bile duct injury and nodular regenerative hyperplasia of the liver in a patient with polyarteritis nodosa. J Hepatol 26:727-730, 1997.
[42]  a) Andonopoulos AP, Tiniakou M, Melachrinou M, Sfontouris H, Bounas A, Zervas C, Zoumbos NC: Sjogren's syndrome in patients with newly diagnosed untreated non-Hodgkin's lymphoma. Rev Rhum (Engl. Ed.) 64:287-292, 1997. b) Andonopoulos AP, Tiniakou M, Melachrinou M, Sfontouris H, Bounas A, Zervas C, Zoumbos NC: Syndrome de Gougerot-Sjogren chez des malades porteurs d' un lymphome non Hodgkinien recemment diagnostique et non encore traite. Rev Rhum (Ed. Fr.) 64:307-312, 1997.
[43]  Andonopoulos AP, Safridi C, Karokis D, Bounas A: Is a purified protein deri-vative skin test and subsequent antituberculous chemoprophylaxis really necessary in systemic rheumatic disease patients receiving corticosteroids? Clin Rheumatol 17:181-185, 1998.
[44]  Andonopoulos AP, Maraziotis T, Rigas G, Yarmenitis S, Papapetropoulos T: Multiple spontaneous intracerebral hemorrhages in a patient with progressive systemic sclerosis. Rev Rhum (Engl. Ed.) 65:437-440, 1998.
[45]  Andonopoulos AP, Christodoulou J, Ballas C, Bounas A, Alexopoulos D: Autonomic cardiovascular neuropathy in Sjogren's syndrome. A controlled study. J Rheumatol 25:2385-2388, 1998.
[46]  Orphanos V, Andonopoulos AP, Kourakli A, Zoumbos NC: Cytokine gene expression in the marrow stromal cells of patients with giant cell arteritis. Clin Exp Rheumatol 16:683-688, 1998.
[47]  Andonopoulos AP, Yarmenitis S, Georgiou P, Bounas A, Vlahanastasi C: Bronchiectasis in systemic sclerosis. A study using high resolution computed tomography. Clin Exp Rheumatol 19:187-190, 2001.
[48]  Andonopoulos AP, Papadimitriou C, Melachrinou M, Meimaris C, Vlahanastasi C, Bounas A, Georgiou P: Asymptomatic gastocnemius muscle biopsy: an extremely sensitive and specific test in the pathologic confirmation of sarcoidosis presenting with hilar adenopathy. Clin Exp Rheumatol 19:569-572, 2001.
[49]  Chroni E, Paschalis C, Vlahanastasi C, Stergiou T, Andonopoulos AP: Multiple sclerosis in the course of systemic sclerosis. Ann Rheum Dis 61:188, 2002.
[50]  Yiannopoulos G, Ravazoula P, Meimaris N, Stavropoulos M, Andonopoulos AP: Dermatomyositis in a patient with adenocarcinima of the gall bladder. Ann Rheum Dis 61:663-664, 2002.
[51]  Andonopoulos AP, Meimaris N, Daoussis D, Bounas A, Yiannopoulos G: Intraarticular anti-tumor necrosis factor α antibody in recalcitrant arthritis of Behcet's disease. Clin Exp Rheumatol (Suppl.) 21:S57-S58, 2003.
[52]  Andonopoulos AP, Meimaris N, Daoussis D, Bounas A, Yiannopoulos G: Experience with infliximab (anti-TNFα monoclonal antibody) as monotherapy for giant cell arteritis. Ann Rheum Dis 62:1116, 2003.
[53]  Andonopoulos AP, Meimaris N, Yiannopoulos G, Pastromas V, Dimopoulos P: Large synovial cysts originating from the sternoclavicular joints in a patient with rheumatoid arthritis. Ann Rheum Dis 62:1119-1120, 2003.
[54]  Bounas A, Melachrinou M, Yiannopoulos G, Meimaris N, Aroukatos P, Kalfarentzos F, Andonopoulos AP: Incidentally discovered asymptomatic necrotizing intraabdominal vasculitis following peripheral gastric bypass surgery for morbid obesity. Ann Rheum Dis 63:211-212, 2004.
[55]  Andonopoulos AP, Melachrinou M, Yiannopoulos G, Meimaris N: Juvenile temporal arteritis. A case report and review of the literature. Clin Exp Rheumatol 22:379-380, 2004.
[56]  Andonopoulos AP, Meimaris N, Daoussis D, Bounas A, Giannopoulos G: Authors' reply to letter by AP Rozin: "Infliximab efficiency and failure" (In "Matters arising"). Ann Rheum Dis 63:752, 2004.
[57]  Karakantza M, Theodorou GL, Meimaris N, Mouzaki A, Andonopoulos AP, Maniatis A: Type-1 and type-2 cytokine-producing CD4+ and CD8+ cells in primary antiphospholipid syndrome. Ann Hematol 83:704-711, 2004.
[58]  Daoussis D, Andonopoulos AP, Liossis SN: Targeting CD40L: A promising therapeutic approach. Clin Diagn Lab Immunol 11:635-641, 2004.
[59]  Ziouti N. Vynios DH, Aletras AJ, Kyriakopoulou D, Mastorakou A, Andonopoulos AP: Changes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in the serum of patients with autoimmune diseases: association with age and disease activity. Clin Chem Lab Med 42:880-888, 2004.
[60]  Nezi G, Giannakouli M, Goura S, Panagiotopoulos E, Andonopoulos AP, Giannopoulou E, Aletras AJ: Prothymosin α suppresses the TGF-β1-enhanced production of tissue inhibitor of metalloproteinases-1 but not of IL-6 in human synovial fibroblasts. Rev Clin Pharmacol Pharmacokin 18:33-35, 2004.
[61]  Yiannopoulos G, Daoussis D, Andonopoulos AP: Arthritis accompanying ileal pouchitis or undifferentiated HLA B27 related spondyloarthropathy? Rheumatol Int 26:565-566, 2006.
[62]  Liossis SN, Andonopoulos AP: Autonomic nervous system dysfunction in Sjogren's syndrome. Curr Rheumatol Rev 2:89-94, 2006.
[63]  Liossis SN, Bounas A, Andonopoulos AP: Mycophenolate mofetil as first-line treatment improves clinically-evident early scleroderma lung disease. Rheumatology 45:1005-1008, 2006.
[64]  Ziouti N, Mastronikolis NS, Andonopoulos AP, Georgakopoulos CD, Vynios DH: Selective inhibition of MMP-2 (Gelatinase A) by Barium Chloride. Analyt Biochem 350:159-161, 2006.
[65]  Vynios DH, Tsagaraki I, Grigoreas GHA, Samiotaki M, Panayotou G, Kyriakopoulou D, Georgiou P, Korbakis D, Panayotou A, Nanouri K, Assouti M, Andonopoulos AP: Autoantibodies against aggrecan in systemic rheumatic diseases. Biochimie 88:767-773, 2006.
[66]  Daoussis D, Antonopoulos I, Andonopoulos AP, Liossis SNC: Increased expression of CD154 (CD40L) on stimulated T cells from patients with psoriatic arthritis. Rheumatology 46:227-231, 2007.
[67]  Yiannopoulos G, Pastromas V, Antonopoulos I, Katsiberis G, Kalliolias G, Liossis SN, Andonopoulos AP: Combination of intravenous pulses of cyclophosphamide and methylprednizolone in patients with systemic sclerosis and interstitial lung disease. Rheumatol Int 27:357-361, 2007.
[68]  Syggelos SA, Giannopoulou E, Gouvousis PA, Andonopoulos AP, Aletras AJ, Panagiotopoulos A: In vitro effects of non-steroidal anti-inflammatory drugs on cytokine, prostanoid and matrix metalloproteinase production by interface membranes from loose hip or knee endoprostheses. Osteoarthritis Cartilage 15:531-542, 2007.
[69]  Kalliolias GD, Georgiou PE, Antonopoulos IA, Andonopoulos AP, Liossis S-NC: Anakinra treatment in patients with adult onset Still's disease is fast, effective, safe and steroid sparing: Experience from an uncontrolled trial. Ann Rheum Dis 66:842-843, 2007.
[70]  Euthymiopoulou K, Aletras A, Ravazoula P, Niarakis A, Daoussis D, Antonopoulos I, Liossis S-N, Andonopoulos AP: Antiovarian antibodies in primary Sjogren's syndrome. Rheumatol Int 27:1149-1155, 2007.
[71]  Starakis I, Mazokopakis E, Siagris D, Liossis S, Karatza C, Antonopoulos A: Catastrophic antiphospholipid syndrome presented with severe hypertension, adult respiratory distress syndrome and unilateral adrenal haemorrhagic infarction. Rheumatol Int 27:781-783, 2007.
[72]  Daoussis D, Siambi V, Liossis S-NC, Yiannopoulos G, Andonopoulos AP: Clinical Image: Bony Ears. Arthritis Rheum 58:611, 2008.
[73]  Androutsopoulos G, Adonakis G, Tsamantas A, Liosis S, Antonopoulos A, Kourounis G: Synchronous primary cancers in a woman with scleroderma. Eur J Gynaecol Oncol 29:548-550, 2008.
[74]  Daoussis D, Andonopoulos AP, Liossis S-NC: Wnt pathway and IL-17: Novel regulators of joint remodeling in rheumatic diseases. Looking beyond the RANK-RANKL-OPG axis. Semin Arthritis Rheum 39:369-383, 2010.
[75]  Daoussis D, Liossis S-NC, Solomou E, Tsanaktsi A, Bounia K, Karampetsou M, Yiannopoulos G, Andonopoulos AP: Evidence that Dickkopf-1 is dysfunctional in ankylosing spondylitis. Arthritis Rheum 62:150-158, 2010.
[76]  Daoussis D, Liossis S-NC, Tsamandas AC, Kalogeropoulou C, Kazantzi A, Sirinian C, Karampetsou M, Yiannopoulos G, Andonopoulos AP: Experience with rituximab in scleroderma. Results from a 1-year, open-label, proof-of-principle study. Rheumatology 49:271-280, 2010.
[77]  Daoussis D, Liossis S-NC, Tsamandas AC, Kalogeropoulou C, Kazantzi A, Sirinian C, Karampetsou M, Yiannopoulos G, Andonopoulos AP: Is there a role for B cell depletion as therapy for scleroderma? A case report and review of the literature. Semin Arthritis Rheum 40:127-136, 2010.
[78]  Daoussis D, Andonopoulos AP: Rituximab in the treatment of systemic sclerosis-associated interstitial lung disease: Comment on the article by Yoo. Rheumatol Int 31:841-842, 2011.
[79]  Kargiotis O, Papathanasopoulos P, Terzis E, Yiannopoulos G, Andonopoulos AP: Bilateral blepharospasm as the presenting symptom of Sjogren's syndrome with evidence of central nervous system involvement. Acta Neuropsychiatrica 22:263-265, 2010.
[80]  Karampetsou MP, Andonopoulos AP, Liossis S-N: Treatment with TNF alpha blockers induces phenotypical and functional aberrations in peripheral B cells. Clin Immunol 140:8-17, 2011.
[81]  Daoussis D, Andonopoulos AP: The emerging role of Dickkopf-1 in bone biology. Is it the main switch controlling bone and joint remodeling? Semin Arthritis Rheum 2011 (in press).
[82]  Daoussis D, Liossis S-N C, Yiannopoulos G, Andonopoulos AP: B cell depletion therapy in systemic sclerosis. Experimental rationale and update on clinical evidence. Int J Rheumatol Volume 2011, Article ID 214013, 7 pages.
[83]  Daoussis D, Liossis S, Tsamandas A, Kalogeropoulou C, Paliogianni F, Sirinian C, Yiannopoulos G, Andonopoulos A: Effect of long term treatment with rituximab on pulmonary function and skin fibrosis in patients with diffuse systemic sclerosis. Clin Exp Rheumatol 2011 (in press).
[84]  Daoussis D, Liossis S-N C, Andonopoulos AP: The role of B cell depletion as a therapeutic approach in systemic sclerosis. World J Rheumatol 2011 (in press).