Advances in Life Sciences

Advances in Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. All articles are rigorously reviewed. The journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms.

Shabir Qureshi

Research Scientist, Saint Louis University, USA

Research Areas

Biochemistry, Biophysics


1998-2003Ph.D Jamia Millia University, New Delhi, India
1995-1997M.ScJamia Hamdard, New Delhi, India
1991-1994B.Sc Kashmir University, Jammu & Kashmir, India


2006-presentResearch Scientist , Saint Louis University, St. Louis, MO., USA 63104
2004-2006Visiting Postdoctoral Fellow, University of Missouri, SaintLouis, St. Louis , USA
2003-2004Research Associate, PRL, Jamia Millia, Jamia Nagar, New Delhi.


Member of American Heart Association/American Stroke Association(AHA/ASA)
Member of American Chemical Society (ACS).
Member of SigmaXi. The Scientific Research Society

Publications: Journals

[1]  Qureshi SH., Lu.Q., Yang L, Rezaie A.R Characterization of the Protein Z-dependent Protease Inhibitor Interactive-sites of Protein Z (under revision Biochim Biophys Acta. May 28, 2014)
[2]  Yang L, P. Dinarvand, Qureshi SH., Rezaie A.R. Engineering D-Helix of Antithrombin in Alpha-1-proteinase Inhibitor Confers Anti-inflammatory Properties on the Chimeric Serpin. Thromb. Haemost. 2014 Feb 13;112(1)
[3]  P. Dinarvand , Hassanian SM., Qureshi SH., Manithody C, Eissenberg JC., Yang L and Rezaie AR.Polyphosphate amplifies proinflammatory responses of nuclear proteins through interaction with receptor for advanced glycation end products and P2Y1 purinergic receptor. Blood. 2014 Feb 6;123(6):935-45
[4]  Qureshi SH., Yang L, Rezaie AR. Contribution of the NH2-terminal EGF-domain of factor IXa to the specificity of intrinsic tenase. Thromb Haemost. 2012 Sep 26;108(6): 1154-64.
[5]  Yang L., Manithody C, Qureshi SH., Rezaie AR. Role of the residues of the 39-loopin determining the substrate and inhibitor specificity of factor IXa. J Biol Chem. 2010, 285(37):28488-95
[6]  Yang L., Manithody C, Qureshi SH,, Rezaie AR. Inhibitory properties of the P1 Tyr variant of antithrombin. Biochemistry. 2010, 49(12); 2680-6.
[7]  Yang L, Manithody C,, Qureshi SH., Rezaie AR Contribution of exosite occupancy by heparin to the regulation of coagulation protease by antithrombin. Thromb Haemost. 2010. 103(2) 277-83.
[8]  Yang L, Qureshi SH., Manithody C, Rezaie AR.Role of P2 glycine in determining the specificity of antithrombin reaction with coagulation proteases. Biochem Biophys Res Commun. 2009, 389(1); 162-7
[9]  Qureshi SH., Yang L, Manithody C, Iakhiaev AV, Rezaie AR. Mutagenesis Studies toward Understanding Allostery in Thrombin. Biochemistry. 2009, 48(34); 8261-70.
[10]  Qureshi SH., Yang L, Manithody C, Rezaie AR. Membrane-Dependent Interaction of Factor Xa and Prothrombin with Factor Va in the Prothrombinase Complex. Biochemistry. 2009, 48 (22); 5034-41.
[11]  Xie F, Qureshi SH., Papadakos GA, Dupureur CM. One- and two-metal ion catalysis: global single-turnover kinetic analysis of the PvuII endonuclease mechanism. Biochemistry. 2008, 47(47);12540-50.
[12]  Rezaie AR, Bae JS, Manithody C, Qureshi SH., Yang L. Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z. J. Biol Chem. 2008, 283(29); 19922-6
[13]  Yang L, Manithody C, Qureshi SH., Rezaie AR. Factor Va alters the conformation of the Na+- binding loop of factor Xa in the prothrombinase complex. Biochemistry. 2008, 47(22); 5976-85
[14]  Qureshi SH., Yang L, Manithody C, Bae JS, Rezaie AR. Functional properties and active- site topographies of factor X Gla- and prothrombin Gla-domain chimeras of activated protein C. Biochim Biophys Acta. 2008, 1780(9); 1080-6.
[15]  Qureshi SH., Manithody C, Bae JS, Yang L, Rezaie AR. Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays. Biophys Chem. 2008, 134(3); 239-45
[16]  Qureshi SH, Yang L, Yegneswaran S, Rezaie A.R. FRET studies with factor X mutants provide insight into the topography of the membrane-bound factor X/Xa. Biochem J.2007, 407; 427-33
[17]  Moza, B., Qureshi, SH., Islam, A., Singh, R.K., Anjum, F., Movahedi, A.A.M., Ahmad, F. A Unique Molten Globule State Occurs during Unfolding of Cytochrome-c by LiClO4 Near Physiological pH and Temperature: STRUCTURAL AND THERMODYNAMIC CHARACTERIZATION . Biochemistry. 2006, 45; 4695-4702.
[18]  Qureshi, SH., Moza, B. and Ahmad, F. Equilibrium Studies of the Effect of Difference in Sequence Homology on the Mechanism of Denaturation of Bovine and Horse Cytochromes-c. Biochimica et Biophysica Acta. 2003, 1646; 49-56.
[19]  Qureshi, SH., Moza, B., Yadav, S., Ahmad, F. Conformational and Thermodynamic Characterization of the Molten Globule State Occurring During Unfolding of Cytochromes-c Using Weak Salt Denaturants. Biochemistry. 2003, 42; 1684-1695.
[20]  C Dupureur, F Xie, S Qureshi, G Papadakos, Use of both novel and classical approaches to evaluate the 1 vs. 2 metal ion nuclease mechanisms JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 24 (6), 685-685

Publications: Conferences/Workshops/Symposiums

[1]  Likui Y., Qureshi SH., Manithody C., Rezaie AR., Role of the Reactive Center Loop of Protein Z-dependent Protease Inhibitor in Determining the Protease Specificity of the Serpin, American Society of Investigative Pathology, 2010Annual Meeting of Experimental Biology. April 24-28, 2010 Anaheim, CA, USA
[2]  Xie, F., Qureshi, SH., and Dupureur, C. The Effect of pH on Specific DNA Binding and Cleavage by PvuII Restriction Endonucleases, XXV Midwest Enzyme Chemistry Conference, October 8, 2005. Department of Chemistry, Loyola University Chicago, IL 60626 USA
[3]  Attended “Third Annual New Enzymology Kinetics Workshop: Kinetic Analysis of Proteins and Nucleic Acids: January 9-12, 2005” Hyatt Regency Hotel, Austin, Texas, USA
[4]  Moza, B., Qureshi, SH.,and Ahmad, F, Effect of Sequence Homology on the Equilibrium Unfolding of Horse and bovine Cytochrome-c,. National Symposium on Biophysics, Indian Institute of Technology, Roorkee, India 2003
[5]  Moza,B.,Qureshi, SH., Yadav, S. and Ahmad, F. Conformational and Thermodynamic Characterization of the Molten Globule State Occurring During Unfolding of Cytochromes-c Using Weak Salt Denaturants, The 2002 Colorado Protein Stability Conference, USA.
[6]  Attended the international symposium on “FRONTIERS IN STRUCTURAL BIOLOGY 25-27 Aug1999” held at National Center for Biological Sciences, Bangalore, India.
[7]  Attended the international Workshop on “PROTEIN STRCTURAL BIOINFORMATICS AND GENOMICS on 28 Aug1999” held at National Center for Biological Sciences, Bangalore, India
[8]  SH Qureshi,AR Rezaie ,Mutagenesis Studies Provide Further Insight into the Role of Membrane in the Prothrombinase Complex