| [1] | Pérez-Rodríguez J, Sánchez-Jiménez F, Márquez J, Medina MA, Quesada AR, Núñez de Castro I Malate-citrate cycle during glycolysis and glutaminolysis in Ehrlich ascites tumor cells. Biochimie 69: 469-474 (1987) |
| [2] | Medina MA, Sánchez-Jiménez F, Márquez J, Pérez-Rodríguez J, Quesada AR, Núñez de Castro I. Glutamine and glucose as energy substrates for Ehrlich ascites tumour cells. Biochem Int 16: 339-347 (1988) |
| [3] | Quesada AR, Medina MA, Márquez J, Sánchez-Jiménez F, Núñez de Castro I. Contribution by host tissues to circulating glutamine in mice inoculated with Ehrlich ascites tumor cells. Cancer Res 48: 1551-1553 (1988) |
| [4] | Medina MA, Quesada AR, Márquez J, Sánchez-Jiménez F, Núñez de Castro I. Inorganic phosphate and energy charge compartmentation in Ehrlich ascites tumour cells in the presence of glucose and/or glutamine. Biochem Int 16: 713-718 (1988) |
| [5] | Medina MA, Sánchez-Jiménez F, Quesada AR, Márquez J, Núñez de Castro I. Effect of palmitate, acetate and glucose on glutamine metabolism in Ehrlich ascites tumor cells. Biochimie 70: 833-834 (1988) |
| [6] | Medina MA, Núñez de Castro I. Evidence of an intracellular dissipative structure. Z Naturforsch 43c: 793-794 (1988) |
| [7] | Quesada AR, Sánchez-Jiménez F, Pérez-Rodríguez J, Márquez J, Medina MA, Núñez de Castro I. Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells. Biochem J 255: 1031-1036 (1988) |
| [8] | Medina MA, Sánchez-Jiménez F, Segura JA, Núñez de Castro I. Transmembrane ferricyanide reductase activity in Ehrlich ascites tumor cells. Biochim Biophys Acta 946: 1-4 (1988) |
| [9] | Segura JA, Medina MA, Alonso FJ, Sánchez-Jiménez F, Núñez de Castro I. Glycolysis and glutaminoluysis in perifused Ehrlich ascites tumour cells. Cell Biochem Function 7: 7-10 (1989) |
| [10] | Urdiales JL, Medina MA, Núñez de Castro I, Sánchez-Jiménez F. Early systemic effects on the hepatic mitochondria of tumour bearing mice. Cancer Lett 44: 179-183 (1989) |
| [11] | Márquez J, Sánchez-Jiménez F, Medina MA, Quesada AR, Núñez de Castro I. Nitrogen metabolism in tumor bearing mice. Arch Biochem Biophys 268: 667-675 (1989) |
| [12] | Márquez J, Matés JM, Quesada AR, Medina MA, Núñez de Castro I, Sánchez-Jiménez F. Altered ornithine metabolism in tumor-bearing mice. Life Sci 45: 1877-1884 (1989) |
| [13] | Luque P, Paredes S, Segura JA, Núñez de Castro I, Medina MA. Mutual effect of glucose and glutamine on their utilization by tumour cells. Biochem Int 21: 9-15 (1990) |
| [14] | Medina MA, Núñez de Castro I. Glutaminolysis and glycolysis interactions in proliferant cells. Int J Biochem 22: 681-683 (1990) |
| [15] | Medina MA, Carrascosa JM, Núñez de Castro I. Short-term effect of glutamine on the incorporation of glucose-carbon into nucleic acids in Ehrlich ascites tumour cells. Biochimie 72: 291-293 (1990) |
| [16] | Medina MA, Sánchez-Jiménez F, Núñez de Castro I. Subcellular distribution of adenine nucleotides in two Ehrlich cell lines metabolizing glucose. Biol Chem Hoppe-Seyler 371: 625-629 (1990) |
| [17] | Yuan Z, Medina MA, Boiteux A, Müller SC, Hess B. The role of fructose-2,6-bisphosphate in glycolytic oscillations in extracts and cells of Saccharomyces cerevisiae. Eur J Biochem 192: 791-795 (1990) |
| [18] | Medina MA, Núñez de Castro I. Plasma membrane oxidoreduction and amino acid transport. Oxidoreduction at the Plasma Membrane. Animals (Crane FL, Morré DJ, Löw H, eds), pp247-255 (1990). CRC Press, Boca Ratón |
| [19] | Medina MA, Luque P, Núñez de Castro I. Mitoxantrone toxicity on Ehrlich ascites tumour cells: Inhibition of the transplasma membrane redox activity. Cell Biochem Function 9: 95-98 (1991) |
| [20] | Medina MA, Quesada AR, Núñez de Castro I. L-Glutamine transport in native vesicles isolated from Ehrlich ascites tumor cell membranes. J Bioenerg Biomembranes 23: 689-697 (1991) |
| [21] | Medina MA, Urdiales JL, Matés JM, Núñez de Castro I, Sánchez-Jiménez F. Diamines interfere with the transport of L-ornithine in Ehrlich-cell plasma-membrane vesicles. Biochem J 280: 825-827 (1991) |
| [22] | Luque P, Márquez J, Núñez de Castro I, Medina MA. Sodium-dependent L-serine transport in plasma membrane vesicles isolated from Ehrlich cells by two-phase compartmentation. J Membrane Biol 123: 247-254 (1991) |
| [23] | Medina MA, García de Veas R, García-Hermoso A, Núñez de Castro I. An experiment in membrane enzyme purification with Triton X-114: avocado pear polyphenoloxidase. Biochem Educ 19: 210-211 (1991) |
| [24] | Luque P, Márquez J, Núñez de Castro I, Medina MA. L-Alanine transport by systems A and ASC in plasma membrane vesicles isolated from Ehrlich cells. Biochem Int 25: 913-918 (1991) |
| [25] | Medina MA, Sánchez-Jiménez F, Márquez J, Quesada AR, Núñez de Castro I. Relevance of glutamine metabolism to tumor cell growth. Mol Cell Biochem 113: 1-15 (1992) |
| [26] | Medina MA, Márquez J, Núñez de Castro I. Interchange of amino acids between tumor and host. Biochem Med Metabol Biol 48: 1-7 (1992) |
| [27] | Medina MA, Del Castillo-Olivares A, Schweigerer L. Plasma membrane redox activity correlates with N-myc expression in neuroblatoma cells. FEBS Lett 311: 99-101 (1992) |
| [28] | Del Castillo-Olivares A, Medina MA. Na+-dependent AIB transport by neuroblastoma cells. FEBS Lett 314: 20-22 (1992) |
| [29] | Del Castillo-Olivares A, Márquez J, Núñez de Castro I, Medina MA. Two phases of ferricyanide reductase activity in Ehrlich cell plasma membranes. Z Naturforsch 47c: 929-931 (1992) |
| [30] | Medina MA, Schweigerer L. A plasma membrane redox system in human retinoblastoma cells. Biochem Mol Biol Int 29: 881-887 (1993) |
| [31] | Medina MA, Del Castillo-Olivares A, Schweigerer L, Núñez de Castro I. Sistemas de transporte de electrones en membrana plasmática de células tumorales. Progresos en Biología Celular (Becerra J, Pérez-Figares JM, Fernández-LLebrez P, eds), pp 177-181 (1993). Universidad de Málaga |
| [32] | Díaz I, Núñez de Castro I, Medina MA. An experiment on the chemical modification of essential histidine residues of lactate dehydrogenase. Biochem Educ 21: 219-220 (1993) |
| [33] | Sánchez-Jiménez F, Matés JM, Urdiales JL, Medina MA, Viguera E, García-Caballero M, Núñez de Castro I. Does histamine behave as a growth-related polyamine? Advances in Biosciences, vol 89 (Brandes et al, eds) pp 43-70 (1993) Pergamon Press, Oxford |
| [34] | Paredes S, Núñez de Castro I, Medina MA. Redox activities in plasma membrane vesicles isolated from papaya (Carica papaya) leaves. J Plant Growth Regul 12: 129-132 (1993) |
| [35] | Medina MA, Del Castillo-Olivares A, Márquez J, Núñez de Castro I. Involvement of essential histidine residue(s) in the activity of Ehrlich cell plasma membrane NADH-ferricyanide oxidoreductase. Biochim Biophys Acta 1190: 20-24 (1994) |
| [36] | Del Castillo-Olivares A, Márquez J, Núñez de Castro I, Medina MA. Characterization of plasma membrane redox activity from Ehrlich cells. Cell Biochem Function 12: 149-152 (1994) |
| [37] | Aledo JC, Segura JA, Medina MA, Alonso FJ, Núñez de Castro I, Márquez J. Phosphate-activated glutaminase expression during tumor development. FEBS Lett 341: 39-42 (1994) |
| [38] | Medina MA, García de Veas R, Schweigerer L. Ascorbic acid is cytotoxic for pediatric tumor cells cultured in vitro. Biochem Mol Biol Int 34: 871-874 (1994) |
| [39] | Medina MA, Núñez de Castro I. Functional reconstitution of Ehrlich cell plasma membrane ferricyandie reductase. Biochem Biophys Res Commun 205: 1109-1113 (1994) |
| [40] | Medina MA, Núñez de Castro I. Plasma membrane redox systems in tumor cells. Protoplasma 184: 168-172 (1995) |
| [41] | Medina MA, García de Veas R, Morata P, Lozano J, Sánchez-Jiménez F. Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines. Breast Cancer Res Treatment 35: 197-194 (1995) |
| [42] | García de Veas R, Schweigerer L, Medina MA. Why is ascorbate toxic to neuroblastoma cell lines and why does this toxicity increase with cell line malignancy? Redox Reports 1: 225-227 (1995) |
| [43] | Molina M, Segura JA, Aledo JC, Medina MA, Núñez de Castro I, Márquez J. Glutamine transport by vesicles isolated from tumour-cell mitochondrial inner membrane. Biochem J 308: 629-633 (1995) |
| [44] | García de Veas R, Schweigerer L, Medina MA. Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in paediatric tumour cells. Effects of tumour cell proliferation modulators on gelatinolytic activity. J Cancer Res Clin Oncol 121: 275-278 (1995) |
| [45] | Fernández-Infantes M, Medina MA. Creating Belousov-Zhabotinsky reactions in a Petri dish. Biochem Educ 23: 219 (1995) |
| [46] | Del Castillo-Olivares A, Esteban del Valle A, Márquez J, Núñez de Castro I, Medina MA. Ehrlich cell plasma membrane redox system is modulated through signal transduction pathways involving cGMP and Ca2+ as second messengers. J Bioenerg Biomembranes 27: 603-609 (1995) |
| [47] | Del Castillo-Olivares A, Medina MA, Núñez de Castro I, Márquez J. Purification and characterization of a plasma membrane ferricyanide utilizing NADH dehydrogenase from Ehrlich tumour cells. Biochem J 314: 587-593 (1996) |
| [48] | Quesada AR, Fajardo I, Rodríguez-Agudo D, Pachón JM, Medina MA. Zymography of extracellular matrix proteases. Biochem Educ 24: 170-171 (1996) |
| [49] | Quesada AR, Medina MA, Núñez de Castro I. Mobilization of glutamine and asparagine in mouse kidney during Ehrlich cell carcinoma development. Cancer Lett 105: 29-32 (1996) |
| [50] | Del Castillo-Olivares A, Rodríguez-Caso L, Márquez J, Núñez de Castro I, Medina MA. Cytoplasmic pH modulates the activity of the plasma membrane electron transport system in Ehrlich ascites tumour cells. Redox Rep 2: 285-287 (1996) |
| [51] | Del Castillo-Olivares A, Esteban del Valle A, Márquez J, Núñez de Castro I, Medina MA. Effects of protein kinase C and phosphoprotein phosphatese modulators on Ehrlich cell plasma membrane redox system activity. Biochim Biophys Acta 1313: 157-160 (1996) |
| [52] | Engel N, Olmo MT, Coleman CS, Medina MA, Pegg AE, Sánchez-Jiménez F. Experimental evidence for structure/activity features in common between mammalian histidine and ornithine decarboxylases. Biochem J 320: 365-368 (1996) |
| [53] | Rodríguez-Caso L, Rodríguez-Agudo D, Del Castillo-Olivares A, Márquez J, Núñez de Castro I, Medina MA. Identification of a Zn2+-sensitive component of Ehrlich cell plasma membrane redox system by CHAPS-agarose polyacrylamide electrophoresis and in situ staining of activity. Biochem Mol Biol Int 41: 75-81 (1997) |
| [54] | Sánchez-Jiménez F, Olmo MT, Ruiz-Checa J, Urdiales JL, Medina MA. Histamina y progresión tumoral: una hipótesis abierta con nuevas perspectivas. Neoplasia 14: 72-76 (1997) |
| [55] | Gómez-Fabre PM, De Pedro E, Medina MA, Núñez de Castro I, Márquez J. Polyamine contents of human breast cancer cells treated wih the cytotoxic agents chlorpheniramine and dehydrodidemnin B. Cancer Lett 113: 141-144 (1997) |
| [56] | Ramírez FJ, Medina MA, Ruíz-Chica J, López-Navarrete JT, Sánchez-Jiménez F. A Raman spectroscopy approach to the interaction between chlorpheniramine and DNA. In Spectroscopy pf Biological Molecules: Modern Trends (Carmona P, ed), pp.383-384, Kluwer, Amsterdam |
| [57] | Medina MA, Del Castillo-Olivares A, Núñez de Castro I. Multifunctional plasma membrane redox systems. BioEssays 19: 977-984 (1997) |
| [58] | Medina MA, Ramírez FJ, Ruíz-Chica J, Chavarría T, López-Navarrete JT, Sánchez-Jiménez F. DNA-chlorpheniramine interaction studied by spectroscopic techniques. Biochim Biophys Acta 1379: 129-133 (1998) |
| [59] | García de Veas R, Schweigerer L, Medina MA. Modulation of the proteolytic balance plasminogen activator/plasminogen activator inhibitor by enhanced N-myc oncogene expression or application of genistein. Eur J Cancer (34: 1736-1740 (1998) |
| [60] | Urdiales JL, Olmo MT, Medina MA, Viguera E, Sánchez-Jiménez F. Análisis estructural y funcional de las L-aminoácido descarboxilasas en células eucariotas. In "Avances en el metabolismo del nitrógeno: De la Fisiología a la Biología Molecular" (Vega JM, Aparicio PJ, Castillo F, Maldonado JM, eds), pp. 509-517 (1998). Servicio de Publicaciones, Universidad de Sevilla |
| [61] | Rodríguez-Caso L, Sánchez-Jiménez F, Medina MA. Putrescine and chlorpheniramine inhibit Ehrlich ascites tumor cell plasma membrane ferricyanide reductase activity. Cancer Lett 132: 165-168 (1998) |
| [62] | Medina MA. Plasma Membrane Redox Systems in Tumor Cells. In Plasma Membrane Redox Systems and their role in Biological Stress and Disease (Asard H, Bérczi A, Caubergs R, eds), pp. 309-324 (1998) Kluwer, Antwerpen |
| [63] | Esteban del Valle A, Del Castillo-Olivares A, Márquez J, Sánchez-Jiménez F, Núñez de Castro I, Medina MA. Plasma membrane redox system activity in mammary tumor cell lines with different proliferation rates. Protoplasma 205: 169-173 (1998) |
| [64] | Medina MA, Quesada AR, Núñez de Castro I, Sánchez-Jiménez F. Histamine, polyamines and cancer. Biochem Pharmacol 57: 1341-1344 (1999) |
| [65] | Fajardo I, Quesada AR, Núñez de Castro I, Sánchez-Jiménez F, Medina MA. A comparative study or the effects of genistein and 2-methoxyestradiol on the proteolytic balance and tumour cell proliferation. Br J Cancer 80: 17-24 (1999) |
| [66] | Olmo MT, Rodríguez-Agudo D, Medina MA, Sánchez-Jiménez F. The PEST regions containing C-termini of mammalian ornithine decarboxylase and histidine decarboxylase play different roles in protein degradation. Biochem Biophys Res Commun 257: 269-272 (1999) |
| [67] | Ruiz-Chica J, Medina MA, Sánchez-Jiménez F, Ramírez FJ. Raman study of the effects of polyamines on DNA: spermine and histamine. J Mol Structure 480-481: 455-458 (1999) |
| [68] | Amores-Sánchez MI, Medina MA. Glutamine, as a precursor of glutathione, and oxidative stress. Mol Genet Metabol 67: 100-105 (1999) |
| [69] | Ruiz-Chica AJ, Urdiales JL, Medina MA, Sánchez-Jiménez F. One century after Fischer: better tools for teaching the stereochemistry of carbohydrates. Biochem Educ 27: 7-8 (1999) |
| [70] | Torés JA, González MD, Pozo E, Urdiales JL, Medina MA, Sánchez-Jiménez F. The antihistaminic chlorpheniramine inhibits in vitro growth of several fungi isolated from harvested fruits. Phytoparasitica 27: 1-12 (1999) |
| [71] | Gallardo F, Gálvez S, Medina MA, Heredia A, Gómez-Moreno C. A practical class for photochemistry and photobiology education based on the production of a combustible. J Chem Educ 77: 375-377 (2000) |
| [72] | Amores MI, Mendoza M, Medina MA. The emergence of complexity theories in biosciences. Biochem Educ 28: 55-56 (2000) |
| [73] | Fajardo I, Urdiales JL, Sánchez-Jiménez F, Medina MA. An experiment on apoptosis induced by polyamine adducts produced in the presence of serum amine oxidase. Biochem Educ 28: 110-112 (2000) |
| [74] | Fajardo I, Díez E, Rodríguez-Nieto S, Rodríguez-Caso C, Quesada AR, Sánchez-Jiménez F, Medina MA. Effects of genistein and 2-methoxyestradiol on matrix metalloproteinases and their inhibitors secreted by Ehrlich ascites tumor cells. Anticancer Res 20: 1691-1694 (2000) |
| [75] | Olmo MT, Urdiales JL, Pegg AE, Medina MA, Sánchez-Jiménez F. In vitro study of proteolytic degradation of rat histidine decarboxylase. Eur J Biochem 267: 1527-1531 (2000) |
| [76] | Amores Sánchez MI, Medina MA. Methods for the determination of plasma total homocysteine: a review. Clin Chem Lab Med 38: 199-204 (2000) |
| [77] | Rodríguez-Agudo D, Olmo MT, Sánchez-Jiménez F, Medina MA. Rat histidine decarboxylase is a substrate for m-calpain in vitro. Biochem Biophys Res Commun 267: 1527-1531 (2000) |
| [78] | Del Castillo-Olivares A, Núñez de Castro I, Medina MA. Dual role of plasma membrane electron transport systems in defense. Critic Rev Biochem Mol Biol 35: 197-220 (2000) |
| [79] | Urdiales JL, Medina MA, Fajardo I, Ramírez J, Ruiz-Chica AJ, Matés JM, Torés JS, Sánchez-Jiménez F. Common biochemcial roles of ornithine-derived polyamines and histamine. In Biogenically Active Amines in Food- Volume III, pp. 132-139 COST 917 Action, European Commisssion (2000) |
| [80] | Sánchez-Jiménez F, Olmo MT, Esteban del Valle A, Urdiales JL, Matés JM, Medina MA. Comparative molecular data on mammalian histidine decarboxylase and ornithine decarboxylase. In Biogenically Active Amines in Food- Volume IV, pp. 115-121 COST 917 Action, European Commisssion (2000) |
| [81] | Quesada AR, Medina MA, Sánchez-Jiménez F (eds). Biología Molecular del Cáncer: Fundamentos y Perspectivas, Colección Thema, SPICUM, Universidad de Málaga (2000) |
| [82] | Medina MA. Ciclo celular, oncogenes y genes supresores tumorales. In Biología Molecular del Cáncer: Fundamentos y Perspectivas, pp. 61-79, Colección Thema, SPICUM, Universidad de Málaga (2000) |
| [83] | Medina MA, Amores-Sánchez MI. Homocysteine: an emergent cardiovascular risk factor? Eur J Clin Invest 30: 754-762 (2000) |
| [84] | Medina MA, Amores-Sánchez MI. Genetic basis of hyperhomocysteinemia. Mol Genet Metabol 71: 478-480 (2000) |
| [85] | Fajardo I, Urdiales JL, Medina MA Sánchez-Jiménez F. Effects of phorbol ester and dexamethasone treatment on histidine decarboxylase and ornithine decarboxylase in basophilic cells. Biochem Pharmacol 61: 1101-1106 (2001) |
| [86] | Fajardo I, Urdiales JL, Paz JC, Chavarría T, Sánchez-Jiménez F, Medina MA. Histamine prevents polyamine accumulation in mouse C57.1 mast cell cultures. Eur J Biochem 268: 768-773 (2001) |
| [87] | Ruiz-Chica AJ, Medina MA, Sánchez-Jiménez F, Ramírez FJ. Fourier Transform Raman study of the structural specificities on the interaction between DNA and biogenic polyamines. Biophys J 80: 443-454 (2001) |
| [88] | Del Valle AE, Paz JC, Sánchez-Jiménez F, Medina MA. Agmatine uptake by cultured hamster kidney cells. Biochem Biophys Res Commun 280: 307-311 (2001) |
| [89] | Paz JC, Sánchez-Jiménez F, Medina MA. Characterization of spermine uptake by Ehrlich tumour cells in culture. Amino Acids 21: 271-279 (2001) |
| [90] | Medina MA, Urdiales JL, Amores-Sánchez MI. Roles of homocysteine in cell metabolism: old and new functions. Eur J Biochem 268: 3871-3882 (2001) |
| [91] | Ruiz-Chica AJ, Khomutov AR, Medina MA, Sánchez-Jiménez F, Ramírez FJ. Interaction of DNA with aminooxy analogue of spermidine –an FT-IR and FT-Raman approach. J Mol Structure 565-566: 253-258 (2001) |
| [92] | Ruiz-Chica AJ, Medina MA, Sánchez-Jiménez F, Ramírez FJ. Characterization of polyamine-induced aggregates of oligodeoxyribonucleotides by Raman spectroscopy. J Mol Structure 565-566: 141-146 (2001) |
| [93] | Ruiz-Chica J, Medina MA, Sánchez-Jiménez F, Ramírez FJ. Raman study of the interaction between polyamines and a GC oligonucleotide. Biochem Biophys Res Commun 285: 437-446 (2001) |
| [94] | Medina MA. Glutamine and cancer. J Nutr 131: 2539S-2542S (2001) |
| [95] | Urdiales JL, Medina MA, Sánchez-Jiménez F. Polyamine metabolism revisited. Eur J Gastroenterol Hepatol 13: 1015-1019 (2001) |
| [96] | Fajardo I, Urdiales JL, Paz JC, Medina MA, Sánchez-Jiménez F. Mast cells: an interesting model to study the role of polyamines on cell life and death. In "Biogenically Active Amines in Food-Volume V: Polyamines, the Gut and Cancer", European Commission (2001) |
| [97] | Rodríguez-Nieto S, González-Iriarte M, Carmona R, Muñoz-Chápuli R, Medina MA, Quesada AR. Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge. FASEB J 10.1096/fj.01-0427fje. (2001) |
| [98] | Rodríguez-Nieto S, Medina MA, Quesada AR. A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res 21: 3457-3460 (2001) |
| [99] | Rodriguez-Nieto S, Chavarría T, Martínez-Poveda B, Sánchez-Jiménez F, Quesada AR, Medina MA Anti-angiogenic effects of homocysteine on cultured endothelial cells. Biochem Biophys Res Commun 293: 497-500 (2002) |
| [100] | Melgarejo E, Carnicas E, Niell FX, Medina MA. Effects of photoacclimation on plasma membrane ferricyanide reductase from the rhodophyta Gracilaria tenuistipitata. Plant Sci 162: 753-759 (2002) |
| [101] | Rodríguez-Caso C, Sánchez-Jiménez F, Medina MA. A modeling and simulation approach to the study of metabolic control analysis. Biochem Mol Biol Educ 30: 169-171 (2002) |
| [102] | Ruiz-Chica AJ, Khomutov AR, Medina MA, Sánchez-Jiménez F, Ramírez FJ. Structural details of the DNA precipitation by an aminooxy analogue of biogenic polyamine spermine.In: International Conference on Raman Spectroscpy, vol 18 (2002) |
| [103] | Fajardo I, Urdiales JL, Paz JC, Chavarría T, Medina MA, Sánchez-Jiménez F. Histamine and polyamine metabolic interplay in mammalian cells. In "Biogenically Active Amines in Food-Volume VI: Biologically active amines", European Commission (2002) |
| [104] | Medina MA, Schwille P. Fluorescence correlation spectroscopy for the detection and study of single molecules in Biology. BioEssays 24: 758-764 (2002) |
| [105] | Olmo MT, Sánchez-Jiménez F, Medina MA, Hayashi H. Spectroscopic analysis of recombinant rat histidine decarboxylase. J Biochem 132: 433-439 (2002) |
| [106] | Chavarría T, Sánchez-Jiménez F, Quesada AR, Medina MA. Homocysteine inhibits the proliferation and invasive potential of HT-1080 human fibrosarcoma cells. Biochem Biophys Res Commun 301: 540-544 (2003) |
| [107] | Medina MA, Urdiales JL, Rodríguez-Caso C, Ramírez FJ, Sánchez-Jiménez F. Biogenic amines and polyamines: similar biochemistry for different physiological missions and biomedical applications. Critic Rev Biochem Mol Biol 38: 23-59 (2003) |
| [108] | Chavarría T, Rodríguez-Nieto S, Sánchez-Jiménez F, Quesada AR, Medina MA. Homocysteine is a potent inhibitor of human tumor cell gelatinases. Biochem Biophys Res Commun 303: 572-575 (2003) |
| [109] | Rodríguez-Caso C, Rodríguez-Agudo D, Sánchez-Jiménez F, Medina MA. Green tea epigallocatechin-3-gallate is an inhibitor of mammalian histidine decarboxylase. Cell Mol Life Sci 60: 1760-1763 (2003) |
| [110] | Ruiz-Chica J, Medina MA, Sánchez-Jiménez F, Ramírez FJ. Raman spectroscopy study of the interaction between biogenic polyamines and an alternating AT oligodeoxyribonucleotide. Biochim Biophys Acta 1628: 11-21 (2003) |
| [111] | Rodríguez-Caso C, Rodríguez-Agudo D, Moya-García AA, Fajardo I, Medina MA, Subramaniam V, Sánchez-Jiménez F. Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability. Eur J Biochem 270: 4376-4387 (2003) |
| [112] | Martínez-Poveda B, Chavarría T, Sánchez-Jiménez F, Quesada AR, Medina MA. An in vitro evaluation of the effects of homocysteine thiolactone on key steps of angiogenesis and tumor invasion. Biochem Biophys Res Commun 311: 649-653 (2003) |
| [113] | González-Iriarte M, Carmona R, Pérez-Pomares JM, Macías D, Medina MA, Quesada AR, Muñoz-Chápuli R. A modified chorioallantoic membrane assay allows for specific detection of endothelial apoptosis induced by antiangiogenic substances. Angiogenesis 6: 251-254 (2003) |
| [114] | Ruiz-Chica AJ, Medina MA, Sánchez-Jiménez F, Ramírez FJ. Characterization by Raman spectroscopy of conformational changes on guanine-cytosine and adenine-thymine oligonucleotides induced by aminooxy analaogues of spermidine. J Raman Spectroscopy 35: 93-100 (2004) |
| [115] | Sánchez-Jiménez F, Medina MA, Urdiales JL, Moya-García AA, Rodríguez-Caso C, Rodríguez-Agudo D. What we know and what we do not about amine-related enzymes. What should we make of it? In “COST Action 922: Health Implications of Dietary Amines. Vol I. Review of Current Status”, pp 45-54. European Commission, 2004 |
| [116] | Ruiz-Chica AJ, Medina MA, Sánchez-Jiménez F, Ramírez FJ. On the interpretation of Raman spectra of 1-aminooxy-spermine/DNA complexes. Nucleic Acid Res 32: 579-589 (2004) |
| [117] | Castro ME, González-Iriarte M, Barrero AF, Fernández A, Muñoz-Chápuli R, Medina MA, Quesada. AR. A study of puupehenone and related compounds as inhibitors of angiogenesis. Int J Cancer 110: 31-38 (2004) |
| [118] | Quesada AR, Medina MA, Muñoz-Chápuli R. Angiogénesis. Consejo Social de la Universidad de Málaga-Servicio de Publicaciones e Intercambio Científico de la Universidad de Málaga, 2004 |
| [119] | Cárdenas C, Quesada AR, Medina MA. Effects of ursolic acid on different steps of the angiogenic process. Biochem Biophys Res Commun 320: 402-408 (2004) |
| [120] | Muñoz-Chápuli R, Quesada AR, Medina MA. Angiogenesis and signal transduction in endothelial cells. Cell Mol Life Sci 61: 2224-2243 (2004) |
| [121] | Moya-García AA, Medina MA, Sánchez-Jiménez F. Mammalian histidine decarboxylase: from structure to function. BioEssays 27: 57-63 (2005) |
| [122] | Jahnz M, Medina MA, Schwille P. A novel homogenous assay for topoisomerase II action and inhibition. ChemBioChem 6: 920-926 (2005) |
| [123] | Ruiz-Chica AJ, Medina MA, Sánchez-Jiménez F, Ramírez FJ. Study by electronic circular dichroism spectroscopy of the interaction between aminooxy analogues of biogenic polyamines and selected oligonucleotides. J Mol Structure 744-747: 691-698 (2005) |
| [124] | Ruiz-Chica AJ. Medina MA, Sánchez-Jiménez, Ramírez FJ. Characterisation by Raman spectroscopy of the interaction between the biogenic polyamines and DNA. In "Biogenically Active Amines in Food-Volume VII, pp. 103-107. European Communities (2005) |
| [125] | Martínez-Poveda B, Quesada AR, Medina MA. Hypericin in the dark inhibits key steps of angiogenesis in vitro. Eur J Pharmacol 516: 97-103 (2005) |
| [126] | Martínez-Poveda B, Quesada AR, Medina MA. Hyperforin, a bio-active compound of St. John’s wort, is a new inhibitor of angiogenesis targeting several key steps of the process. Int J Cancer 117: 775-780 (2005) |
| [127] | Navas-Delgado I, Rodríguez-Caso C, Roldán-García MM, Medina MA, Aldana-Montes JF. A semantic tool for analyzing interaction among transcription factors. In: IADIS International Conference Applied Computing 2005, volume 1 (Guimaraes N, Isaías P, eds), pp- 512-518 (2005) |
| [128] | Rodríguez-Agudo D, Ren S, Hylemon P, Redford K, Montañez R, Medina MA, Pandak W. STARD5: a novel cytosolic START domain protein capable of intracellular directional transport of cholesterol to the Golgi/ER. Hepatology 42: 508A (2005) |
| [129] | Rodríguez-Caso C, Medina MA Solé RV. Topology, tinkering and evolution of the human transcription factor network. FEBS J 272: 6423-6434 (2005) |
| [130] | Medina MA, Correa-Fiz F, Rodríguez-Caso C, Sánchez-Jiménez F. A comprehensive view of polyamine and histamine metabolism to the light of new technologies. J Cell Mol Med 9: 854-864 (2005) |
| [131] | Melgarejo E, Medina MA Paz JC, Sánchez-Jiménez F, Urdiales JL. Real-time RT-PCR analysis of human histidine decarboxylase, a new marker for several types of leukemia and cancer. Oncol Rep 15: 193-197 (2006) |
| [132] | Rodríguez-Agudo D, Ren S, Hylemon P, Montañez R, Redford K, Natarajan R, Medina MA,Gil G, Pandak W. Localization of StarD5 cholesterol binding protein. J Lipid Res 47: 1168-1175 (2006) |
| [133] | Medina MA, Martínez-Poveda B, Amores-Sánchez MI, Quesada AR. Hyperforin: more than an antidepressant bioactive compound? Life Sci 79: 105-111 (2006) |
| [134] | Quesada AR, Muñoz-Chápuli R, Medina MA. Anti-angiogenic drugs: from bench to clinical trials. Med Res Reviews 26: 483-530 (2006) |
| [135] | Rodríguez-Caso C, Montañez R, Cascante M, Sánchez-Jiménez F, Medina MA. Mathematical modeling of polyamine metabolism in mammals. J Biol Chem 281: 21799-21812 (2006) |
| [136] | Medina MA. The pursuit of creativity in biology. BioEssays 28: 1151-1152 (2006) |
| [137] | Cárdenas C, Quesada AR, Medina MA. Evaluation of the anti-angiogenic effect of aloe-emodin. Cell Mol Life Sci 63: 3083-3089 (2006) |
| [138] | Martínez-Poveda B, Amores-Sánchez MI, Quesada AR, Medina MA. El hipérico: una fuente de compuestos bioactivos con un amplio espectro de acción. Ann R Acad Nac Farm LXXII: 583-598 (2006) |
| [139] | Medina MA, Aldana JF, Villatoro FR, Claros G, Urdiales JL, Trelles O, Sánchez-Jiménez F. Amine system project. Inflamm Res 56: S1-S2 (2007) |
| [140] | Sánchez-Jiménez F, Montañez R, Correa-Fiz F, Chaves P, Rodríguez-Caso C, Urdiales JL, Aldana JF, Medina MA. The usefulness of post-genomics tools for characterization of the amine cross-talk in mammalian cells. Biochem Soc Trans 35: 381-385 (2007) |
| [141] | González FJ, Quesada AR, Sevilla I, Baca JJ, Medina MA, Amores J, Díaz JM, RiusDíaz F, Marques E, Alba E. Prognostic value of serum angiogenic activity in colorectal cancer patients. J Cell Mol Med 11: 120-128 (2007) |
| [142] | Chaves P. Correa-Fiz F, Melgarejo E, Urdiales JL, Medina MA, SánchezJIménez F. Development of an expression macroarray for amine metabolism-related genes. Amino Acids 33: 315-222 (2007) |
| [143] | Montañez R, Sánchez-Jiménez F, Aldana-Montes JF, Medina MA. Polyamines: metabolism to systems biology and beyond. Amino Acids 33: 283-289 (2007) |
| [144] | Medina MA, Muñoz-Chápuli R, Quesada AR. Challenges of antiangiogenic cancer therapy: trials and errors, and renewed hope. J Cell Mol Med 11: 374-382 (2007) |
| [145] | Martínez-Poveda B, Muñoz-Chápuli R, Rodríguez-Nieto S, Quintela JM, Fernández A, Medina MA, Quesada AR. IB05204, a dichloropyridodithienotriazine, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther 6: 2675-2685 (2007) |
| [146] | Quesada AR, Medina MA, Alba E. Playing only one instruments may be not enough: limitations and future of the antiangiogenic treatment of cancer. BioEssays 29: 1159-1168 (2007) |
| [147] | Melgarejo E, Medina MA, Sánchez-Jiménez F, Botana LM, Domínguez M, Escribano L, Orfao A, Urdiales JL. (-) Epigallocatechin-3-gallate interferes with mast cell adhesiveness, migration and its potential to recruit monocytes. Cell Mol Life Sci 64: 2690-2671 (2007) |
| [148] | Martínez-Poveda B, Medina MA, Quesada AR. Angiogénesis. En: Tratamiento farmacológico y de soporte de los tumors cerebrales. (Balaño-Quintero C, coord.). Permanyer, Barcelona (2007) |
| [149] | Montañez R, Rodríguez-Caso C, Sánchez-Jiménez F, Medina MA. In silico analysis of arginine catabolism as a source of nitric oxide or polyamines in endothelial cells. Amino Acids 34: 223-229 (2008) |
| [150] | Martínez-Poveda B, Quesada AR, Medina MA. The antiangiogenic 8-epipuupehedione behaves as a potential antileukemic compound against HL-60 cells. J Cell Mol Med 12: 701-706 (2008) |
| [151] | Rodríguez-Alonso J, Montañez R, Rodríguez-Caso L, Medina MA. Homocysteine is a potent modulator of plasma membrane electron transport systems. J Bioenerg Biomembr 40: 45-51 (2008) |
| [152] | Navas-Delgado I, Montañez R, Medina MA, Urdiales JL, Aldana JF, Sánchez-Jiménez F. The Amine System Project: Systems Biology in Practice. In. Computational Intelligence in Bioinformatics (Kelemen A, Abraham A, Chen Y, eds), pp 277-292. Springer, Berlin, 2008 |
| [153] | Medina MA. Hyperhomocysteinemia and occlusive vascular disease. An emergent role for fibroblast growth factor 2. Circ Res 102: 869-870 (2008) |
| [154] | Martínez-Poveda B, Muñoz-Chápuli R, Riguera R, Medina MA, Quesada AR. DTD, an antiinflammatory ditraizine, inhibits angiogenesis in vitro and in vivo. J Cell Mol Med 12: 1211-1219 (2008) |
| [155] | Melgarejo E, Medina MA, Sánchez-Jiménez F, Urdiales JL. Monocyte chemoattractant protein-1: a key mediator in inflammatory processes. Int J Biochem Cell Biol 41: 998-1001 (2009) |
| [156] | Medina MA, Muñoz-Chápuli R, Quesada AR. Receptores del VEGF y angiogénesis. En: Angiogénesis y Cáncer (Alba E, Quesada AR, eds), pp 121-147. TACTIS MD, Barcelona, 2009 |
| [157] | Medina MA. Metodología para el estudio de la angiogénesis. En: Angiogénesis y Cáncer (Alba E, Quesada AR, eds), pp 203-239. TACTIS MD, Barcelona, 2009 |
| [158] | Reyes-Palomares A, Montañez R, Real-Chicharro A, Chniber O, Kerzazi A, Navas-Delgado I, Medina MA, Aldana-Montes JF, Sánchez-Jiménez F. Systems Biology Metabolic Modeling Assistant (SBMM): an ontology-based tool for the integration of metabolic data in kinetic modeling. Bioinformatics 25: 834-835 (2009) |
| [159] | Reyes-Palomares A, Sánchez-Jiménez F, Medina MA. First steps in computational systems biology: a practical session in mtabolic modeling and simulation. Biochem Mol Biol Educ 37: 178-181 (2009) |
| [160] | Correa-Fiz F, Reyes-Palomares A, Ruiz-Pérez MV, Medina MA, Sánchez-Jiménez F. Roles of biogenic amines in emergent and rare diseases. In Biological Aspects of Biogenic Amines, Polyamines and Conjugates (Dandrifosse G, ed), pp 399-419, Transworld Research Network, Kerala (2009) |
| [161] | Melgarejo E, Medina MA, Sánchez-Jiménez F, Urdiales JL. Epigallocatechin gallate reduces human monocyte mobility and adhesion in vitro. Br J Pharmacol 158: 1705-1712 (2009) |
| [162] | Reall-Chicharro A, Ruiz-Mostazo I, Navas-Delgado I, Kerzazi A, Chniber O, Sánchez-Jiménez F, Medina MA, Aldana-Montes JF. Protopia: a protein-protein interaction tool. BMC Bioinformatics 10: S17 (2009) |
| [163] | Melgarejo E, Urdiales JL, Sánchez-Jiménez F, Medina MA. Targeting polyamines and biogenic amines by green tea epigallocatechin-3-gallate. Amino Acids 38: 519-523 (2010) |
| [164] | Montañez R, Medina MA, Solé RV, Rodríguez-Caso C. When metabolism meets topology: reconciling metabolite and reaction networks. BioEssays 32: 246-256 (2010) |
| [165] | Martínez-Poveda B, Verotta L, Bombardelli E, Quesada AR, Medina MA. Tetrahydrohyperforin and octahydrohyperforin are two new potent inhibitors of angiogenesis. Plos ONE 5(3): e9558 |
| [166] | Melgarejo E, Medina MA, Sánchez-Jiménez F, Urdiales JL. Targeting of histamine producing cells by EGCG: a greend art agains inflammation? J Physiol Biochem 66: 265-270 (2010) |
| [167] | Quesada AR, Medina MA, Muñoz-Chápuli R, Ponce ALG. Do not say ever never more: the ins and outs of antiangiogenic therapies. Current Pharmaceutical Design 16: 3932-3957 (2010) |
| [168] | Quesada AR, Medina MA. Angiogenesis in Cancer: therapeutic targets and angiogenesis inhibitors. In Angiogeneis & Therapeutic Targets in Cancer, vol 1 (Chatterjee M, Rana A, Rana B, eds), pp. 45-67. Bentham Sci Pub, 2010 |
| [169] | Pino-Ángeles A, Moya-García AA, Medina MA, Sánchez-Jiménez. Enzymolgoy in Histamine Biogenesis. In Biomedical Aspects of Histamine (Shahid M, Khardori N, Khan RA, Tripathi T, eds), pp. 33-59. Springer, 2010 |
| [170] | Navas-Delgado I, Real-Chicharro A, Medina MA, Sánchez-Jiménez F, Aldana-Montes JF. Social pathway annotation: extensions of the systems biology metabolic modellling assistant. Brief Bioinformatics (first published online October 21, 2010 doi:10.1093/bib/bbq061) |
| [171] | García-Caballero M, Marí-Beffa M, Medina MA Quesada AR. Dimethylfumarate inhibits angiogenesis in vitro and in vivo. A possible role for its antipsoriatic effect? J Invest Dermatol 131: 1347-1355 (2011) |
| [172] | Ruiz-Pérez MV, Sánchez-Jiménez F, Quesada AR, Medina MA. A re-evaluation of the mitogenic effect of serotonin on vascular endothelial cells. J Biol Reg Homeostatic Agents 25: 13-20 (2011) |
| [173] | Moya-García AA, Rodríguez-Agudo D, Hayashi H, Medina MA, Urdiales JL, Sánchez-Jiménez F. Analysis of mammalian histidine decarboxyñase dimerization interface reveals an elecetrostatic hotspot important for catalyitic site topology and function. J Chem Theor Comput 7:1935-1942 (2011) |
| [174] | Cárdenas C, Quesada AR, Medina MA. Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. Plos One 6: e23407 (2011) |
| [175] | Montañez R, Sánchez-Jiménez F, Quesada AR, Medina MA. Exploring and challengingthe network of angiogenesis. Sci Rep 1: 61 (2011) |
| [176] | Rodríguez-Agudo D, Calderón-Domínguez M, Ren S, Marques D, Redford K, Medina MA, Hylemon P, Gil G, Pandak WM. Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts. Biochim Biophys Acta 1811: 597-606 (2011) |
| [177] | Gazák R, Valentová K, Fuksová K, Marhol P, Kuzma M, Medina MA, Oborná I, Ulrichová J, Kren V. Synthesis and antiangiogenci activity of new silybin galloyl esters. J Med Chem 54: 7397-7407 (2011) |
| [178] | Reyes-Palomares A, Montañez R, Sánchez-Jiménez F, Medina MA. A combined model of hepatic polyamine and sulfur amino acid metabolism to analyze S-adenosyl methionine availability. Amino Acids (in press) |
| [179] | Correa-Fiz F, Reyes-Palomares A, Fajardo I, Melgarejo E, Gutiérrrez A, García-Ranea JA, Medina MA, Sánchez-Jiménez F. Regulatory cross-talk of mouse liver polyamine and methionine metabolic pathwasy: A systemic approach to its physiopathological consequences. Amino Acids (in press) |