Advances in Life Sciences

Advances in Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. All articles are rigorously reviewed. The journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms.

Victor Jin

Editorial Board Member of Advances in Life Sciences

Assistant Professor, Department of Biomedical Informatics, The Ohio State University, USA

Research Areas

Computational Genomics, Systems Biology

Education

2003M.ScComputer Science, University of Ottawa, Canada
2001Ph.DSupermolecular/Biological Chemistry, Queen's University, Canada
1988B.ScGeneral Science, Fudan University, Shanghai, P.R.China

Experience

2009-presentAssistant Professor, Department of Biomedical Informatics, The Ohio State University
2008-2009Assistant Professor, Department of Biology, Bioinformatics Program, The University of Memphis
2005-2007Postdoctoral Research Scientist with Professor Peggy J. Farnham, Genome Center, University of California at Davis
2003-2005Up on the Roof Postdoctoral Fellow with Professor Ramana Davuluri, Human Cancer Genetics, The Ohio State University
1995-1997Research Assistant, Department of Chemistry, National University of Singapore
1988-1995Research Scientist, Shanghai Institute of Pharmaceutical Industry

Academic Achievement

Travel Enrichment Funds-College of Arts & Sciences, University of Memphis 2008
Conference Travel Fellowship-ISMB 2006, Brazil
Up on the Roof Fellowship-The Ohio State University, 2003~2005
Ontario Graduate Scholarship-Provincial Level, 2000 ~ 2001
Queen's Graduate Fellowship, 1999~2000

Membership

Membership in Professional Societies: International Society for Computational Biology
Membership in AAAS Scienc

Publications: Journals

[1]  "Study on isolation and purification of superoxide dismutase", Yang, G., Qin, K., Chen, W., UJin, V.X.U and Zhao, Y. Journal of Industry Biochemistry, 2, 119-120. (1993).
[2]  "Complexes of platinum (II) or palladium (II) with 1, 10-phenantroline and amino acids", UJin, V.X.*U and Ranford, R.D. Inorg. Chim. Acta, 304, 38-44, (2000). (impact factor 2.322).
[3]  "Assembly and Dissociation of α--Bis(N-(N, N1. "Study on isolation and purification of superoxide dismutase", Yang, G., Qin, K., Chen, W., UJin, V.X.U and Zhao, Y. Journal of Industry Biochemistry, 2, 119-120. (1993).
[4]  "Assembly and Dissociation of α--Bis(N-(N, N"-dimethylethylenediamine))alkane Threads" UJin, V.X.U, Macartney, D.H. and Buncel, E. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 53, 197-203 (2005). (impact factor 1.165).
[5]  "Kinetic and spectroscopic studies on α-and β-cyclodextrin rotaxanes with (μ-N, N"-bis(4-pyridinylmethylene)--alkanediimine)bis[pentacyanoferrate(II)] threads" UJin, V.X.U, Macartney, D.H. and Buncel, E. Canadian Journal of Chemistry, 83, 185-191 (2005). (impact factor 1.42).
[6]  "α-and β-Cyclodextrin [2]Rotaxanes with (Diethylenetriamine)platinum(II) Stoppers" UJin, V.X.U, Macartney, D. H., Buncel, E. Canadian Journal of Chemistry, 83, 2091-2097 (2005). (impact factor 1.42).
[7]  "Platinum(II) triamine antitumor complexes: structure activity relationship with Guanosine 5'-Monophosphate (5'-GMP)" UJin, V.X.* Tan, S.I. and Ranford, R.D. Inorg. Chim. Acta. 358, 677-686 (2005). (impact factor 2.322).
[8]  "Loss of estrogen signaling triggers epigenetic silencing of its downstream targets in breast cancer" Leu, Y-W, Yan, P. S., Fan, M., UJin, V.X.U, Liu, J.C., Curran, E.M., Welshons, W.V., Wei, P PS.H., Davuluri, R.V., Plass, C., Nephew, K.P. and Huang, T.H.-M. Cancer Res., 64, 8184-8192 (2004). PMID: 15548683 (impact factor 7.54).
[9]  "Identifying estrogen receptor α target genes using integrated computational genomics and chromatin immunoprecipitation microarray" UJin, V.X.U, Leu, Y.-W., Liyanarachchi, S., Sun, H., Huang T.H-M. and Davuluri, R.V. Nucleic Acid Res. 32, 6627-6635 (2004). PMID: 15608294 (impact factor 7.48).
[10]  "OMGProm: an integrated resource of orthologous mammalian gene promoters" Palaniswamy, S.K., UJin, V.X.U, , Sun, H. and Davuluri, R.V. Bioinformatics. 21, 835-836 (2005). PMID: 15531605 (impact factor 4.93).
[11]  "ERTargetDB: an integral information resource of transcription regulation of ER target genes" UJin, V.X.U, Sun, H., Pohar, T.T., Liyanarachchi, S., Palaniswamy, S.K., Huang T.H-M. and Davuluri, R.V. Journal of Molecular Endocrinology 35, 225-230 (2005). PMID: 16216904 (impact factor 3.22).
[12]  "MPromDb: An integrated resource for annotation and visualization of mammalian gene promoters and ChIP-chip experimental data" Sun, H., Palaniswamy, S. K., Pohar, T.T., UJin, V.X.U, Huang, T. H.-M. and Davuluri, R.V. Nucleic Acid Res. 34, D98-103 (2006). PMID: 16381984 (impact factor 7.48).
[13]  "Genome-wide Analysis of Core Promoters from Conserved Human and Mouse Orthologous Pairs" UJin, V.X.U, Singer, G. and Davuluri, R.V. BMC Bioinformatics 7, 114 (2006). PMID: 16522199 (impact factor 3.43).
[14]  "Combinatorial Analysis of Transcription Factor Partners Reveals Recruitment of c-MYC to ERα-Responsive Promoters" Cheng, A.S., UJin, V.X.U, Yan, P.S., Fan, M., Leu, Y.W, Chan, M.W., Plass, C., Nephew, K.P., Davuluri, R.V. and Huang, T.H.-M. Molecular Cell 21, 393-404 (2006). PMID: 16455494 (impact factor 14.61) 14. "A Mixture Model Based Discriminate Analysis for Identifying New Ordered Motif-Pairs in Gene Motif Modules Directly Regulated by Estrogen Receptor-" Li, L., Chen, A.S., UJin, V.X.U, Paik H.H., Fan, M., Li, X., Zhang, W., Robarge, J., Davuluri, R.V., Kim, S., Huang, , T.H.-M. and Nephew, K.P. Bioinformatics. 22, 2210-2216 (2006). PMID: 16809387 (impact factor 4.93).
[15]  "Suz12 Silences Large regions of the genome in a cell type-specific manner" Squazzo, S.L., O"Geen, H., Komashko, V.M., Krig, S.R., UJin, V.X.U, Jang, S., Green, R., Magueron, R., Reinberg, D. and Farnham, P.J. Genome Research 16, 890-900 (2006). PMID: 16751344 (impact factor 13.34).
[16]  "Locating Mammalian Transcription Factor Binding Sites: A Survey of Computational and Experimental Techniques" Elnitski, L., UJin, V.X.U, Farnham, P.J.P Pand Jones, S.J.M. P PGenome Research (Review), 16, 1455-1464 (2006). In Advance on October 19, 2006, 10.1101/gr.4140006. PMID: 17053094 (impact factor 11.34).
[17]  "A computational genomics approach to identify cis-regulatory modules for chromatin immunoprecipitation microarray data-a case study using E2F1 in cancers" UJin, V.X.U, Rabinovich, A., Squazzo, S.L., Green, R. and Farnham, P.J. Genome Research, 16, 1585-1595 (2006). In Advance on October 19, 2006, 10.1101/gr.5520206. PMID: 17053090 (impact factor 13.34).
[18]  "Detecting Localized Interspersed Motifs in Genomic Sequences" UJin, V.X.U, and Turcotte, M. IEEE Transactions on Instrumentation and Measurement. 56, 1770-1775 (2007). (impact factor 1.03).
[19]  "Identification of genes directly regulated by the oncogene ZNF217 using ChIP-chip assays" Krig, S, UJin, V.X. (Co-1UPUstUPU)U, Bieda, M., O"Geen, H., Green, R. and Farnham, P.J. Journal of Biological Chemistry, 282, 9703-9712 (2007). PMID: 17259635 (impact factor 5.33).
[20]  "Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches" UJin, V.X.U, O"Geen, H., Iyengar, S. Green, R. and Farnham, P.J. Genome Research, 17, 807-817 (2007) (ENCODE issue). PMID: 17567999 (impact factor 13.34).
[21]  "A comprehensive ChIP chip analysis of E2F1, E2F4 and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members" Xu, X., Bieda, M., Jin, V.X., Rabinovich, A., Oberley, M.J., Green, R. and Farnham, P.J. Genome Research, 17, 1550-1561 (2007). In Advance on Oct 1 2007. 10.1101/gr6783507. PMID: 17908821 (impact factor 13.34).
[22]  "Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer" Cheng, Y.Y., Yu, J., Wong, Y.P., Man, E.P.S., To, K.F., Jin, V.X., Li, J., Tao, Q., Sung, J.J.Y., Chan, F.K.L., Leung, W.K. British Journal of Cancer, 97, 895-901 (2007). PMID: 17848950 (impact factor 4.35).
[23]  "E2F in vivo binding specificity: comparison of consensus vs. non-consensus binding sites" Rabinovich, A, Jin, V.X., Rabnovich, R., Xu, X, and Farnham, P.J. Genome Research, 18, 1763-1777 (2008). PMID: 18836037 (impact factor 13.34).
[24]  "N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor" Cotterman, R, . Jin, V.X. (Co-1st), Krig, S., Lemen, J., Wey, A., Farnham, P.J. and Knoepfler., P. Cancer Research 68, 9654-9662 (2008). PMID: 19047142 (impact factor 7.54).
[25]  "Chemical genomics of cancer chemopreventive dithiolethiones" Tran, N.Q.T., Xu, L., Phan, V.T., Goodwin, S.B., Rahman, M., Jin, V.X., Sutter, C.H., Roebuck, B.D., Kenslen, T., George, E.O. and Sutter, T.R. Carcinogenesis 30, 480-6 (2009). PMID: 19126641 (impact factor 4.8).
[26]  "Epigenetic Changes During Disease Progression in a Murine Model of Human Chronic Lymphocytic Leukemia" Chen, S.-S., Raval, A., Johnson, A.J., Hertlein, E., Liu, T.-H., Jin, V.X., Sherman, M., Liu, S., Dawson, D.W., Williams, K.E., Lanasa, M., Liyanarachchi, S., Lin, T.S., Marcucci, G., Pekarsky, Y., Davuluri, R.V., Croce, C.M., Guttridge, D.C., Teitell, M.A., Byrd, J.C. and Plass, C. PNAS. 106, 13433-13438 (2009). PMID: 19666576 (impact factor 9.43).
[27]  "W-ChIPMotifs: a web application tool for de novo motif discovery from ChIP-based high throughput data" Jin, V.X.*, Apostolos, J., Nagisetty, N.S.V., Farnham, P.J. Bioinformatics, 25, 3191-3193 (2009). PMID: 19797408 (impact factor 4.93).
[28]  "HRTBLDb: an informative data resource for Hormone Receptors Target Binding Loci" Kennedy, B., Gao, W., Huang, T.H.-M., Jin, V.X*. Nucleic Acids Res. 38, D676-D681 (2010). In Advance, Sep 22, 2009. PMID: 19773424 (impact factor 7.48).
[29]  "Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263 (ZNF263)" Frietze, S., Lan, X., Jin, V.X.(Co-corresponding)* and Farnham, P.J.* Journal of Biological Chemistry 285, 1393-1403 (2010). Nov 2, 2009 Online In advance. PMID: 19887448 (impact factor 5.33).
[30]  "Multivalent Epigenetic Marks Confer Microenvironment-Responsive Epigenetic Plasticity to Ovarian Cancer Cells" Bapat, S.A., Jin, V.X. (Co-1st), Berry, N., Balch, C., Sharma, N., Kurrey, N., Zhang, S., Fang, F., Lan, X., Li, M., Kennedy, B., Bigsby, R.M., Huang, T.H.-M., Nephew, K. Epigenetics, 5, 716-729 (2010). PMID: 20676026 (impact factor 4.58).
[31]  "DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination" Hsiao, S.-H., Lee, K.-D., Hsu, C.-C., Tseng, M.-J., Jin, V.X., Sun, W.-S., Hung, Y.-C., Yeh, K.-T., Yan, P., Lai, Y.-Y., Sun, H., Lu, Y.-J., Chang, Y.-S., Shaw-Tsai, J., Huang, T.H.-M. and Leu, Y.-W. Biochem and Biophys Res Commun, 400, 305-12 (2010). PMID: 20727853 (impact factor 2.55).
[32]  "An improved profile-level domain liker propensity index for protein domain boundary prediction" Zhang Y., Liu, B., Dong, Q. and Jin, VX. Protein & Peptide Letters, 18, 7-16, (2011). PMID: 20955175 (impact factor 1.76).
[33]  "W-ChIPeaks: a comprehensive web application tool to process ChIP-chip and ChIP-seq data" Lan, X., Bonneville, R., Apostolos, J., Wang, W. and Jin, V.X.* Bioinformatics, 27, 428-430 (2011). PMID: 21138948 (impact factor 4.93).
[34]  "ZNF274 recruits the histone methyltransferase SETDB1 to 3"ends of zinc finger genes" Frietze, S., O"Geen, H., Blahnik, K.R., Jin, V.X. and Farnham, P.J. PLoS ONE, 5, e15082 (2010). PMID: 21170338 (impact factor 4.35).
[35]  "Inference of hierarchal regulatory network of estrogen-dependent breast cancer through ChIP-based data" Gu, F., Wu, J., Parvin, J., Huang, T.H-M., Jin, V.X.* BMC Systems Biology, 4, 170 (2010). PMID: 21167036 (impact factor 4.06).
[36]  "Epigenetic silencing mediated through activated PI3K/AKT signaling in breast cancer" Zuo, T., Liu, T.-M., Lan, X., Weng, Y.-I., Shen, R., Gu, F., Huang, Y.W., Liyanarachchi, S., Deatherage, D.E., Hsu, P.Y., Taslim, C., Ramaswamy, B., Shapiro, C.L., Lin, H.J., Cheng, A.S.L., Jin, V.X. and Huang, TH-M. Cancer Research, 71, 1752-1762 (2011). PMID: 21216892 (impact factor 7.54).
[37]  "Genome-wide analysis of E2F1 mutant proteins reveals that N-and C terminal protein interaction domains do not participate in targeting E2F1 to the human genome". Cao, A.R., Rabinovich, R., Xu, M., Xu, X., Jin, V.X., and Farnham, P.J. J. Biol. Chem., 286, 11985-11996 (2011). In Advance on Feb 10. PMID: 21310950.
[38]  "Functional analysis of KAP1 genomic recruitment" Iyengar, S., Ivanov, A., Jin, V.X., Rauscher, F.J. 3rd and Farnham, P.J. Mol Cell Biol., 31, 1833-47 (2011). In Advance on Feb 22. PMID: 21343339.
[39]  "Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells" Teng, I.-W., Hou, P.-C., Lee, K.-D., Chu, P.-Y., Yeh, K.T., Jin, V.X., Tseng, M.-J., Tsai, S.-J., Chang, Y.-S., Wu, C.-S., Sun, H.S., Tsai, K.-D., Jeng, L.B., Nephew, K.P., Huang, T.H.-M., Hsiao, S.-H., and Yu-Wei Leu, Y.-W. Cancer Research, 71, 4653-4663 (2011). PMID: 21518779. (impact factor 8.35).
[40]  "Integrative identification of core genetic regulatory modules via a structural model-based clustering method" Tang, B., Chen, S.-S. and Jin, V.X.* International Journal of Computational Biology and Drug Design (IJCBDD), 4, 127-145 (2011). PMID: 21712564.
[41]  "High resolution detection and analysis of CpG dinucleotides methylation using MBD-seq technology" Lan, X., Adams, C., Landers, M., Dudas, M., Krissinger, D., Marnellos, G., Bonneville, R., Xu, M., Wang, J., Huang, T.H.-M., Meredith, G., and Jin, V.X.* PLoS One, 6, e22226 (2011). PMID: 21779396. (impact factor 4.46).
[42]  "ChIP-seq defined genome-wide map of TGFβ/SMAD4 targets: implications with clinical outcome of ovarian cancer" Kennedy, B.A., Deatherage, D.E., Gu, F., Tang, B., Chan, M.W.Y., Nephew, K.P., Huang, T.H.-M. and Jin, V.X.* PLoS One, 6, e22606 (2011). PMID: 21799915 (impact factor 4.46).
[43]  "Experimental and computational challenges from array-based to sequence-based ChIP techniques" Lan X. and Jin V.X.* Current Bioinformatics (Review), Accepted.

Publications: Conferences/Workshops/Symposiums

[1]  "The sources and applications of polyunsaturated fatty acids" (Review), UJin, V.X.U and Yang, G. Symposium on commercialization of functional food and its additives. pp47-53. Oct 1995, Shanghai, P.R China.
[2]  "Detecting localized interspersed motifs in genomics sequences" UJin, V.X.U and Turcotte, M. Proceedings of 23rd IEEE Instrumentation and Measurement Technology Conference, 23, 267-270, (2005).
[3]  "Genome-wide analysis of KAP1 binding reveals auto-regulation of KRAB-ZNFs" O"Geen, H, Squazzo, S.L., Iyenger, S., Blahnik, K., Jin, V.X., Green, R., Farnham, P.J. FEBS J, 274 (Suppl 1), 79-79 (2007).
[4]  "De Novo identification of in vivo binding sites from ChIP-chip data" Jin, V.X.*, Rabinovich A., O"Geen, H., Iyenger, S. and Farnham, P.J. BMC Bioinformatics, 9 (Suppl 7), P24, (2008).
[5]  "Toward Comprehensive Feature Extraction from High-Throughput NGS Sequences" Tang, B., Hsu, H.-K., Huang, T.-H.-M. and Jin, V.X.*, CET 2011, accepted.
[6]  "Protein Binding Site Prediction by Combining Order Profile Propensities and Hidden Markov Support Vector Machine" Liu, B. and Jin, V.X.* CET 2011, Accepted.

Publications: Books/Book Chapters

[1]  "Using ChIPMotifs for de novo motif discovery of OCT4 and ZNF263from ChIP-based high throughput experiments". Kennedy, B.A., Lan, X., Huang, T.H.-M., Farnham, P.J. and Jin, V.X.* In press, Editors Wang, J., Tan A.C., and Tian, T. Humana Press.-dimethylethylenediamine))alkane Threads" UJin, V.X.U, Macartney, D.H. and Buncel, E. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 53, 197-203 (2005). (impact factor 1.165).