Advances in Life Sciences

Advances in Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. All articles are rigorously reviewed. The journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms.


Rajasingh Johnson

Editorial Board Member of Advances in Life Sciences

Associate Professor, University of Kansas Medical Center, USA

Research Areas

Stem Cell, Reprogramming of Somatic Cell Signaling, Cell Signaling, Regenerative Medicine

Education

2004-2007PostdoctoralPostdoctoral Fellowship at Vanderbilt University, Nashville and Tufts University, Boston
1992-1998Ph.DDoctor of Philosophy, Zoology, SGPGI Lucknow and Avadh University, India
1986-1988MasterZoology, Madras University, India
1983-1986MasterZoology, Madurai Kamaraj University, India

Experience

2011-presentAssistant Professor, Department of Medicine, Division of Cardiovascular Diseases, Cardiovascular Research Institute, University of Kansas Medical Center, Kansas City, KS-66160
2008-2011Research Assistant Professor, Department of Pharmacology, University of Illinois at Chicago, IL
2007-2008Research Assistant Professor, Department of Medicine, Northwestern University, Chicago, IL
2005-2007Senior Research Associate, Department of Cardiovascular Research, St. Elizabeth's Medical center, Boston, MA
2004-2005Postdoctoral Fellow, Department of Neuro-immunology, Vanderbilt University Medical Center, Nashville TN
1999-2003Chief Embryologist, Samad IVF, Samad Hospital, Trivandrum
1995-1999Embryologist, Assisted Reproductive Technology Center, Sri Ramakrishna Hospital, Coimbatore, a collaborative center of National University Hospital, Singapore
1992-1995Research Fellow, Department of Immunology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Lucknow
1989-1992Associate Research Officer, Department of Virology & Immunology, Christian Medical College & Hospital, Vellore

Academic Achievement

Junior Research Fellowship Award, Awarded by Indian Council of Medical Research (ICMR) from Feb. 1992 to Jan. 1993
Senior Research Fellowship Award, Awarded by Council of Scientific and Industrial Research (CSIR) from Feb. 1993 to Mar. 1995
Best Research Paper Award on Conference Conducted by Caritas Christi Health Care Institution of Boston on March 23, 2006
Young Investigator Fellowship Award on 59th Annual Symposium on Cancer Research "Stem cells in Cancer and Regenerative Medicine" Houston, Texas 2006
New Investigator Travel Award, at the 4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences Colorado 2007

Membership

2011-served as a member in judge's panel for KUMC Resident, postdoc and fellow research day
2009-present committee member in Basic Cell and Regenerative Cell Biology grant study section, American Heart Association
2004-present, Supervisor Member, American Association of Bioanalysts
2005-present, Member, American Heart Association
2005-present, Member, American Association for the Advancement of Science
2004-2006 Member, American society of Endocrinology
2004-2006 Member, Association of Reproductive Health Professionals
2000-2003, Member, Indian Society for Assisted Reproduction year 2003
2002-2004, Member, The Federation of Obstetric & Gynaecological Societies of India

Publications: Journals

[1]  Johnson Rajasingh, Jayakumar T, Siddiqui MR, Gomes I, Gao XP, Kishore R, Malik AB. Improvement of Cardiac Function in Mouse Myocardial Infarction after Transplantation of Epigenetically-Modified Bone Marrow Progenitor Cells. PLoS One. 2011;6(7):e22550. Epub. Jul 22.
[2]  Siddiqui MR, Komarova YA, Vogel SM, Gao XP, Bonini MG, Johnson Rajasingh, Zhao YY, Brovkovych V, Malik AB. Caveolin-1-eNOS Signaling Regulates p190RhoGAP-A Nitration and Endothelial Permeability. J. Cell Biology 193 (5): 841-850, 2011.
[3]  Krishnamurthy P, Johnson Rajasingh, Lambers E, Qin G, Losordo DW, Kishore R. IL-10 attenuates inflammation mediated left ventricular remodeling after myocardial infarction via activation of STAT-3 and suppression of HuR. Circulation Research 104:e9-18, 2009.
[4]  Suriano R, Chaudhuri D, Johnson Rajasingh, Lambers E, Kishore R, Tiwari RK. 17-b-estradiol mobilizes bone marrow endothelial progenitor cells to tumors. Cancer Research 66 (15), 6038-42, 2008.
[5]  Johnson Rajasingh, Lambers E, Hamada H, Bord E, Thorne T, Goukassian I, Krishnamurthy P, Rosen KM, Ahluwalia D, Zhu Y, Qin G, Losordo DW, Kishore R. Cell-free Embryonic Stem Cell Extract-mediated derivation of Multipotent Stem Cells from NH3T3 Fibroblasts for Functional and Anatomical Ischemic Tissue Repair. Circulation Research 102(11):e107-17, 2008.
[6]  Johnson Rajasingh, Hamada H, Qin G, Bord E, Silver M, Mehta S, Goukassain D, Losordo DW, Kishore R. STAT3-dependent mouse Embryonic Stem Cell Differentiation into Cardiomyocytes: Analysis of Molecular Signaling and Therapeutic Efficacy of Cardiomyocyte Pre-committed mES in a Mouse Model of myocardial Infarction Circulation Research 101:910-918. 2007
[7]  Johnson Rajasingh, Bord E, Qin G, Ii M, Silver M, Hamada H, Goukassian D, Zhu Y, Losordo DW, Kishore R. Enhanced Voluntary Alcohol Consumption Following Estrogen Supplementation Negates Estrogen-mediated Vascular Repair in Ovariectomized Mice. Endocrinology 148(8):3618-24, 2007
[8]  Johnson Rajasingh, Bord E, Luedemann C, Asai J, Hamada H, Thorne T, Qin G, Goukassian D, Zhu Y, Losordo DW, Kishore R. IL-10-induced TNF-alpha mRNA Destabilization is Mediated via IL-10 Suppression of p38 MAP Kinase Activation and Inhibition of HuR Expression FASEB J. 12:2112-2124, 2006
[9]  Johnson Rajasingh and Bright JJ. 15-Deoxy-Δ12, 14-Prostaglandin J2 Regulates Leukemia Inhibitory Factor Signaling through JAK-STAT Pathway in Mouse Embryonic Stem Cell. Experimental Cell Research 312: 2538-2546, 2006.
[10]  Raikwar HP, Muthian G, Johnson Rajasingh, Johnson C, Bright JJ. PPARγ antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-Deoxy-Δ12, 14-Prostaglandin J2. Journal of Neuroimmunology 178: 76-86, 2006
[11]  Muthian G, Raikwar HP, Johnson Rajasingh, Bright JJ. 1, 25 Dihydroxyvitamin D3 Modulates JAK-STAT Pathway in IL-12/IFN|gamma| Axis Leading to Th1 Response in Experimental Allergic Encephalomyelitis. Journal of Neuroscience Research 83: 1299-1309, 2006
[12]  Johnson Rajasingh, Raikwar HP, Muthian G, Johnson C, Bright JJ. Curcumin induces growth-arrest and apoptosis by blocking the constitutive activation of JAK-STAT signaling pathway in T cell Leukemia. Biochem. Biophysi. Res. Commun. 340: 359-368, 2006.
[13]  Muthian G, Raikwar HP, Johnson C, Johnson Rajasingh, Bright JJ. COX-2 Inhibitors modulate Th1 response in experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocytes. Journal of Clinical Immunology, 26: 73-85, 2006.
[14]  Johnson Rajasingh and Pillai SM. Successful ICSI pregnancy in a 56-year-old woman. Ind. J. Multi. Res. 1 (2): 27-29, 2005.
[15]  Raikwar HP, Muthian G, Johnson Rajasingh, Johnson C, Bright JJ. Bisphenol A Diglycidyl ether A PPAR antagonist exacerbates neural antigen–induced Th1 response and experimental allergic encephalomyelitis. Journal of Neuroimmunology Oct;167(1-2):99-107, 2005.
[16]  Saxena S., Johnson Rajasingh, Biswas S, Kumar D, Shinohara T, Singh VK. Cellular immune response to retinal S-antigen and interphoto-receptor retinoid binding protein fragments in Eales' disease patients. Pathobiology, 67 (1): 39-44, 1999.
[17]  Nirmal S, Cherian T, Samuel BU, Johnson Rajasingh, Raghupathy P and John TJ. Immune response of infants to fractional doses of intradermally administered inactivated poliovirus vaccine. Vaccine 16 (9-10): 928-931, 1998.
[18]  Gupta D, Singh VK, Johnson Rajasingh, Shinohara T, Mishra R, Agarwal SS. Cellular immune response of patients with juvenile rheumatoid arthritis to retinal antigens and their synthetic peptides. Immunol. Res., 15: 74-83, 1996.
[19]  Johnson Rajasingh, Singh VK, Singh V, Sharma K, Agarwal SS. Cellular immune response to retinal S-antigen and Interphoto-receptor retinoid binding protein fragments in idiopathic human uveitis. Ind. J. Med. Res., 103: 222-226, 1996.
[20]  Samuel BU, Ponnuraj E, Johnson Rajasingh, John TJ. Experimental poliomyelitis in bonnet monkey. Clinical features, Virology and Pathology. Dev. Biol. Stand., 78: 71-78, 1993.
[21]  John TJ, Nambiar A, Samuel BU, and Johnson Rajasingh. Ulnar nerve inoculation of poliovirus in bonnet monkey; a new model to investigate neurovirulence. Vaccine, 10 (8): 529-532, 1992.
[22]  Samuel BU, Cherian T, Johnson Rajasingh, Raghupathy P, John TJ. Immune response of infants to inactivated poliovirus vaccine injected intradermally. Vaccine, 10 (2): 135, 1992.

Publications: Conferences/Workshops/Symposiums

[1]  Johnson Rajasingh, Sathy M. Pillai and S. Meera and Manjula. Comparison of IVF results with Day 2 verses Day 3 embryo transfer. 8th International congress on ART and advances in infertility management, 2002.
[2]  Johnson Rajasingh, Sathy M. Pillai and S. Meera, V. Preetha and R. Lekshmy. A prospective and comparative study of IUI pregnancy in two different swim-up methods. 9th International congress on ART and advances in infertility management, 2003.
[3]  Gladson Muthian, Himanshu P. Raikwar, Johnson Rajasingh, Caroline Johnson and John J. Bright. PPARγ agonists inhibits IFNγ-induced activation of JAK-STAT pathway in microglia (XXXV International Congress of Physiological Sciences: San Diego, California, 2005)
[4]  Johnson Rajasingh, Evelyn Bord, Douglas Losordo and Raj Kishore. Turning the clock back: Induced de-differentiation of somatic cells into multipotent cells that trans-differentiate into vascular lineage cells. Best research paper award on Caritas Christi Health Care research day March 23, 2006.
[5]  Rajasingh Johnson, Hiromichi Hamada, Evelyn Bord, Douglas W. Losordo and Raj Kishore. De-differentiation of Somatic Cells into Stem cells for Regenerative Medicine. 59th Annual Symposium on Cancer Research "Stem cells in Cancer and Regenerative Medicine" Houston, Texas 2006
[6]  Johnson Rajasingh, Hiromichi Hamada, Gangjian Qin, Douglas W. Losordo and Raj Kishore. De-differentiation and Epigenetic Reprogramming of Somatic Cells into Pluripotent Stem Like Cells and Its Therapeutic Efficacy in Mouse Model of Acute Myocardial Ischemia. Selected for presentation at 4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, Colorado 2007.
[7]  Johnson Rajasingh, Hiromichi Hamada, Gangjian Qin, Douglas W. Losordo and Raj Kishore. STAT3-Dependent Cross Talk Signaling Mechanism of LIF and BMP-2 in Mouse Embryonic Stem Cell Differentiation into Cardiomyocytes and its Therapeutic Efficacy in Mouse model of Myocardial Infarction. Selected for presentation at 4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, Colorado 2007.
[8]  Haruki Sekiguchi, Kentaro Jujo, Johnson Rajasingh, Tina Thorne, Trevor Clarke, Sol Misener, John Kenny, Masaki Ii, Douglas W Losordo. Neural stem cells contribute to peripheral nerve repair by coordinated angiogenesis and neurogenesis. AHA 2007.