Advances in Life Sciences

Advances in Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. All articles are rigorously reviewed. The journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms.


Gianluca Tettamanti

Editorial Board Member of Advances in Life Sciences

Lecturer, University of Insubria, Italy

Research Areas

Apoptosis, Autophagy, Cell Death, Insects, Host-Parasitoid Interactions, Immunity

Education

2003Ph.DUniversity of Insubria, Italy
1997B.ScUniversity of Milano, Italy

Experience

2005-presentAssistant Professor (Zoology), DBSM, University of Insubria
2004Visiting Scientist, Randall Division of Cell and Molecular Biophysics, King's College London
2003-2004Research Fellow, DBSF, University of Insubria
2000-2003PhD Student, DBSF, University of Insubria
1998Visiting Scientist, Randall Institute, King's College London
1997-1998Research associate, Department of Biology, University of Milano

Academic Achievement

Research in Bioscience Award (Regio Insubrica, CH), 1999
Research in Bioscience Award (Regio Insubrica, CH), 2003
"P. Pasquini" Award for Developmental Biology (Unione Zoologica Italiana, I), 2005

Membership

Italian Society of Zoology (UZI), 2001-present
British Society for Developmental Biology (BSDB), 2007-present

Publications: Journals

[1]  de Eguileor M., Grimaldi A., Lanzavecchia G., Tettamanti G. and Valvassori R., 1998. Dimensional and numerical growth of helical fibers in leeches: an unusual pattern. The Journal of Experimental Zoology, 281:171-187
[2]  de Eguileor M., Grimaldi A., Boselli A., Tettamanti G., Lurati S., Valvassori R. and Lanzavecchia G., 1999. Possible roles of extracellular matrix and cytoskeleton in leech body wall muscle. Journal of Microscopy, 196: 6-18
[3]  de Eguileor M., Tettamanti G., Grimaldi A., Boselli A., Scarì G., Valvassori R., Cooper E.L. and Lanzavecchia G., 1999. Histopathological changes after induced injury in leeches. Journal of Invertebrate Pathology, 74: 14-28
[4]  de Eguileor M., Grimaldi A., Tettamanti G., Valvassori R., Cooper E.L. and Lanzavecchia G., 2000. Different types of response against foreign antigens by leech leukocytes. Tissue & Cell, 32: 40-48
[5]  de Eguileor M., Giordana B., Leonardi M.G., Grimaldi A., Tettamanti G., Fiandra L., Valvassori R. and Lanzavecchia G., 2000. Integumental amino acid uptake in a carnivorous predator mollusc (Sepia officinalis, Cephalopoda). Tissue & Cell, 32: 389-399
[6]  de Eguileor M., Grimaldi A., Tettamanti G., Boselli A., Valvassori R., Cooper E.L. and Lanzavecchia G., 2000. Lipopolysaccharide-dependent induction of leech leukocytes that cross-react with vertebrate cellular differentiation markers. Tissue & Cell, 32: 437-445
[7]  de Eguileor M., Grimaldi A., Tettamanti G., Congiu T., Protasoni M., Reguzzoni M., Valvassori R. and Lanzavecchia G., 2001. Ultrastructure and functional versatility of hyrudinean botryoidal tissue. Tissue & Cell, 33: 332-341
[8]  de Eguileor M., Grimaldi A., Tettamanti G., Valvassori R., Leonardi M.G., Giordana B., Tremblay E., Digilio M.C. and Pennacchio F., 2001. Larval anatomy and structure of absorbing epithelia in the aphid parasitoid Aphidius ervi Haliday (Hymenoptera, Braconidae). Arthropod Structure & Development, 30: 27-37
[9]  de Eguileor M., Grimaldi A., Tettamanti G., Ferrarese R., Congiu T., Protasoni M., Perletti G., Valvassori R. and Lanzavecchia G., 2001. Hirudo medicinalis: a new model system for testing activators and inhibitors of angiogenesis. Angiogenesis, 4: 299-312
[10]  de Eguileor M., Tettamanti G., Grimaldi A., Congiu T., Ferrarese R., Perletti G., Valvassori R., Cooper E.L. and Lanzavecchia G., 2003. Leeches: immune response, angiogenesis and biomedical applications. Current Pharmaceutical Design, 9: 133-147
[11]  Perletti G., Marras E., Dondi D., Grimaldi A., Tettamanti G., Valvassori R. and de Eguileor M., 2003. Assessment of the biological activity of an improved naked-DNA vector for angiogenesis gene therapy on a non-mammalian model. International Journal of Molecular Medicine, 11: 691-696
[12]  Tettamanti G., Grimaldi A., Ferrarese R., Palazzi M., Perletti G., Valvassori R., Cooper E.L., Lanzavecchia G. and de Eguileor M., 2003. Leech responses to tissue transplantation. Tissue & Cell, 35: 199-212
[13]  Tettamanti G., Grimaldi A., Valvassori R., Rinaldi L. and de Eguileor M., 2003. Vascular Endothelial Growth Factor is involved in neoangiogenesis in Hirudo medicinalis (Annelida, Hirudinea). Cytokine, 22: 168-179
[14]  Grimaldi A., Tettamanti G., Rinaldi L., Brivio M.F., Castellani D. and de Eguileor M., 2004. Muscle differentiation in tentacle of Sepia officinalis (Mollusca) is regulated by muscle regulatory factors (MRFs) related proteins. Development Growth & Differentiation, 46: 83-96
[15]  Perletti G., Osti D., Marras E., Tettamanti G. and de Eguileor M., 2004. Generation of VSV-G pseudotyped lentiviral particles in 293T cells. Journal of Cellular and Molecular Medicine, 8: 142-143
[16]  Grimaldi A., Tettamanti G., Brivio M.F., Valvassori R. and de Eguileor M., 2004. Differentiation of slow and fast fibers in tentacles of Sepia officinalis (Mollusca). Development Growth & Differentiation, 46: 181-193
[17]  de Eguileor M., Tettamanti G., Grimaldi A., Perletti G., Congiu T., Rinaldi L. and Valvassori R., 2004. Hirudo medicinalis: avascular tissues for clear-cut angiogenesis studies? Current Pharmaceutical Design, 10: 1979-1988
[18]  Grimaldi A.*, Tettamanti G.*, Martin B.L., Gaffield W., Pownall M.E. and Hughes S.M., 2004. Hedgehog regulation of superficial slow muscles fibres in Xenopus and the evolution of tetrapod trunk myogenesis. Development, 131: 3249-3262 (*equal contribution)
[19]  Grimaldi A., Tettamanti G., Rinaldi L., Valvassori R. and de Eguileor M., 2004. Role of cathepsin B in leech wound healing. Invertebrate Survival Journal, 1: 36-48
[20]  Tettamanti G., Grimaldi A., Rinaldi L., Arnaboldi F., Congiu T., Valvassori R. and de Eguileor M., 2004. The multifunctional role of fibroblasts during wound healing in Hirudo medicinalis (Annelida, Hirudinea). Biology of the Cell, 96: 443-455
[21]  Tettamanti G., Grimaldi A., Ferrarese R., Rinaldi L., Bortolotto A., Di Guardo G. and de Eguileor M., 2004. A comparative study of sporta perimedullaris muscolosa in the renicule of six species of cetaceans. The Italian Journal of Zoology, 71: 115-121 (Errata 71: 271-273)
[22]  Ferrarese R., Brivio M., Congiu T., Falabella P., Grimaldi A., Mastore M., Perletti G., Pennacchio F., Sciacca L., Tettamanti G., Valvassori R. and de Eguileor M., 2005. Early suppression of immune response in Heliothis virescens larvae by the endophagous parasitoid Toxoneuron nigriceps. Invertebrate Survival Journal, 2: 60-68
[23]  Tettamanti G., Grimaldi A., Congiu T., Perletti G., Raspanti M., Valvassori R. and de Eguileor M., 2005. Collagen reorganization in leech wound healing. Biology of the Cell, 97: 557-568
[24]  Rinaldi L., Basso P., Tettamanti G., Grimaldi A., Terova G., Saroglia M. and de Eguileor M., 2005. Oxygen availability causes morphological changes and a different VEGF/Flk-1/HIF-2 expression pattern in sea bass (Dicentrarchus labrax) gills. The Italian Journal of Zoology, 72: 103-111
[25]  Grimaldi A., Moriondo A., Sciacca L., Guidali M.L., Tettamanti G. and Negrini D., 2006. Functional arrangement of diaphragmatic initial lymphatic network. American Journal of Physiology-Heart and Circulatory Physiology, 291: H876-885
[26]  Tettamanti G., Malagoli. D., Marchesini E., Congiu T., de Eguileor M. and Ottaviani E., 2006. Oligomycin A induces autophagy in the IPLB-LdFB insect cell line. Cell and Tissue Research, 326: 179-186
[27]  Grimaldi A., Caccia S., Congiu T., Ferrarese R., Tettamanti G., Rivas-Pena M., Perletti G., Valvassori R., Valvassori R., Giordana B., Falabella P., Pennacchio F. and de Eguileor M., 2006. Structure and function of the extraembryonic membrane persisting around the larvae of the parasitoid Toxoneuron nigriceps. Journal of Insect Physiology, 52: 870-880
[28]  Grimaldi A., Tettamanti G., Perletti G., Valvassori R. and de Eguileor M., 2006. Hematopoietic cell formation in leech wound healing. Current Pharmaceutical Design, 12: 3033-3041
[29]  Tettamanti G., Malagoli D., Benelli R., Albini A., Grimaldi A., Perletti G., Noonan D.M., de Eguileor M. and Ottaviani E., 2006. Growth factors and chemokines: a comparative functional approach between invertebrates and vertebrates. Current Medicinal Chemistry, 13: 2737-2750
[30]  Grimaldi A., Tettamanti G., Guidali M.L., Brivio M.F., Valvassori R. and de Eguileor M., 2007. A hedgehog-like signal is involved in slow muscle differentiation in Sepia officinalis (Mollusca). Invertebrate Survival Journal, 4: 1-9
[31]  Hammond C.L., Hinits Y., Osborn D.P.S., Minchin J., Tettamanti G. and Hughes S.M., 2007. Signals and myogenic regulatory factors restrict pax3/7 expression to dermomyotome-like tissue in zebrafish. Developmental Biology, 302: 504-521
[32]  Tettamanti G., Grimaldi A., Casartelli M., Ambrosetti E., Ponti B., Congiu T., Ferrarese R., Rivas-Pena M.L., Pennacchio F. and de Eguileor M., 2007. Programmed cell death and stem cell differentiation are responsible for midgut replacement in Heliothis virescens during prepupal instar. Cell and Tissue Research, 330: 345-359
[33]  Tettamanti G., Grimaldi A., Pennacchio F. and de Eguileor M., 2007. Lepidopteran larval midgut during prepupal instar: digestion or self-digestion? Autophagy, 3: 630-631
[34]  Klionsky D.J., ….., Tettamanti G., …….and Deter R.L., 2008. Guidelines for the use and interpretation of assays for monitoring autophagy in higher Eukaryotes. Autophagy, 4: 151-175
[35]  Tettamanti G., Saló E., Gonzáles-Estévez C., Felix D.A., Grimaldi A. and de Eguileor M., 2008. Autophagy in invertebrates: insights into development, regeneration and body remodeling. Current Pharmaceutical Design, 14: 116-125
[36]  Tettamanti G., Malagoli. D., Ottaviani E. and de Eguileor M, 2008. Oligomycin A and the IPLB-LdFB insect cell line: actin and mitochondrial responses. Cell Biology International, 32: 287-292
[37]  Grimaldi A., Tettamanti G., Acquati F., Bossi E., Guidali M.L., Banfi S., Monti L., Valvassori R. and de Eguileor M., 2008. A hedgehog homolog is involved in muscle formation and organization of Sepia officinalis (Mollusca) mantle. Developmental Dynamics, 237: 659-671
[38]  Tettamanti G., Grimaldi A., Pennacchio F. and de Eguileor M., 2008. Toxoneuron nigriceps parasitization delays midgut replacement in fifth instar Heliothis virescens larvae. Cell and Tissue Research, 332: 371-379
[39]  Grimaldi A., Bianchi C., Greco G., Tettamanti G., Noonan D.M., Valvassori R. and de Eguileor M., 2008. In vivo isolation and characterization of stem cells with diverse phenotypes using growth factor impregnated biomatrices. Plos ONE, 3: e1910
[40]  Tettamanti G. and Malagoli D., 2008. In vitro methods to monitor autophagy in Lepidoptera. Methods in Enzymology, 451: 685-709
[41]  Grimaldi A., Banfi S., Gerosa L., Tettamanti G., Noonan D.M., Valvassori R. and de Eguileor M., 2009. Identification, isolation and expansion of stem cells involved in leech muscle regeneration. Plos ONE, 4: e7652
[42]  Brevini T., Pennarossa G., Antonini S., Paffoni A., Tettamanti G., Montemurro T., Radaelli E., Lazzari L., Rebulla P., Scanziani E., de Eguileor M., Benvenisty N., Ragni G. and Gandolfi F., 2009. Cell lines derived from human parthenogenetic embryos can display aberrant centriole distribution and altered expression levels of mitotic spindle check-point transcripts. Stem Cells Reviews and Reports, 5: 340-352
[43]  Tettamanti G., Cattaneo A.G., Gornati R., de Eguileor M., Bernardini G. and Binelli G., 2010. Phylogenesis of brain-derived neurotrophic factor (BDNF) in vertebrates. Gene, 450: 85-93
[44]  Tettamanti G. and Grimaldi A., 2010. Current perspectives on muscle regeneration and diseases. Current Pharmaceutical Design, 16: 904-905
[45]  Grimaldi A., Banfi S., Bianchi C., Greco G., Tettamanti G., Noonan D.M., Valvassori R. and de Eguileor M., 2010. The leech: a novel invertebrate model for studying muscle regeneration and diseases. Current Pharmaceutical Design, 16: 968-977
[46]  Malagoli D., Abdalla F.C., Cao Y., Feng Q., Fujisaki K., Gregorc A., Matsuo T., Nezis I.P., Papassideri I.S., Silva-Zacarin E.C.M., Tettamanti G. and Umemiya-Shirafuji R. Autophagy and its physiological relevance in arthropods: current knowledge and perspectives. Autophagy, 6: 575-588
[47]  Li Q., Deng X., Yang W., Huang Z., Tettamanti G., Cao Y. and Feng Q., 2010. Autophagy, apoptosis and ecdysis-related gene expression in the silk gland of the silkworm (Bombyx mori) during metamorphosis. Canadian Journal of Zoology, 88: 1169-1178
[48]  Brevini T., Pennarossa G., de Eguileor M., Tettamanti G., Ragni G., Paffoni A. and Gandolfi F., 2011. Parthenogenetic cell lines: an unstable equilibrium between pluripotency and malignant transformation. Current Pharmaceutical Biotechnology, 12: 206-212
[49]  Cappellozza S., Saviane A., Tettamanti G., Squadrin M., Vendramin E., Paolucci P., Franzetti E. and Squartini A., 2011. Identification of Enterococcus mundtii as a pathogenic agent involved in the "flacherie" disease in Bombyx mori L. larvae reared on artificial diet. Journal of Invertebrate Pathology, 106: 386-393
[50]  Tettamanti G., Cao Y., Feng Q., Grimaldi A. and de Eguileor M., 2011. Autophagy in Lepidoptera: more than old wine in new bottle. Invertebrate Survival Journal, 8: 5-14
[51]  Grimaldi A., Banfi S., Vizioli J., Tettamanti G., Noonan D.M. and de Eguileor M., 2011. Cytokine loaded biopolymers as a novel strategy to study stem cells during wound-healing processes. Macromolecular Bioscience, in press

Publications: Books/Book Chapters

[1]  de Eguileor M., Tettamanti G., Grimaldi A., Ferrarese R., Perletti G., Valvassori R., Cooper E.L. and Lanzavecchia G., 2002. "Leech immune responses: contributions and biomedical applications" in "A new model for analyzing antimicrobial peptides with biomedical applications" Vol. 343 pp. 93-102 NATO Science Series: Life and Behavioural Sciences, Edited by: E. Cooper and M. Biley, IOS Press, The Netherlands
[2]  de Eguileor M., Grimaldi A., Tettamanti G., Valvassori R. and Cooper E.L., 2003. "State of the art for the immune system in leeches" in "The new panorama of animal evolution" pp. 139-145, Edited by: A. Legakis, S. Sfenthourakis, R. Polymeni, and M. Thessalou-Legaki, Pensoft publishers, Sofia & Moscow
[3]  Tettamanti G. and Casartelli M., 2010. "Lepidopteran midgut stem cells: a new tool for cell biology and physiological studies" in "Pluripotent stem cells", pp. 173-184, Edited by: D.W. Rosales and Q.N. Mullen, Nova Science Publishers, New York
[4]  de Eguileor M., Grimaldi A. and Tettamanti G. "Il sistema circolatorio" in "Biotecnologie entomologiche". Liguori Editore, in press