Advances in Life Sciences

Advances in Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. All articles are rigorously reviewed. The journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms.

Ki Churl Chang

Editorial Board Member of Advances in Life Sciences

Professor, School of Medicine Gyeongsang National University, South Korea

Research Areas

Cardiovascular Pharmacology Heme Oxygenase Related Pharmacology Inflammation and Critical Care Medicine

Education

1982-1984Ph.DSeoul National University, College of Medicine
1980-1982MSSeoul National University, College of Medicine
1971-1975BSSungkyunkwan University, College of Pharmacy

Experience

2007-presentProfessor of Department of Pharmacology, School of medicine Gyeongsang National University
2007-2008President of Korean Pharmacological Society
2001-2003Chairman, Institute of Health Sciences, Gyeongsang National University
1997The William Harvery Research Institute, UK, Visiting Professor
1995-presentGyeongsang National University, College of Medicine, Professor
1994-1995Tokyo University, College of Veterinary Medicine, Department of Pharmacology, Visiting Professor
1993-2001Institute of Cardiovascular Research, Gyeongsang Nationa University, Chairman
1990-presentGyeongsang National University, College of Medicine, Head of Department of Pharmacology
1990-1995Gyeongsang National University, College of Medicine, Associate Professor
1988-1989University of Cincinnati, College of Medicine, Department of Pharmacology, (Dr. Robert M. Rapoport), Research Fellow
1986New York Down State Medical Center, Department of Pharmacology, (Dr. Robert F. Furchgott), WHO Fellow
1985-1990Gyeongsang National University, College of Medicine, Assistant Professor
1984-1986Gyeongsang National University, College of Medicine, Professor
1983-1985Gyeongsang National University, College of Medicine, Instructor
1981-1983Seoul National University, College of Medicine, Teaching Assistant

Academic Achievement

2010: Awarded by Excellent researcher by Ministry of Health and Welfare
2006: Awarded by AstraZeneka " Virtual Drug development"
2000: Awarded by the Gyeongsang National University, College of Medicine
1999: Awarded as by the Korean Pharmacological Society
1998: Travelers Award by International Union of Pharmacology
1992: Awarded by the Association of Korean Science and Technology

Publications: Journals

[1]  Kim YM, Kim MY, Kim HJ, Roh GS, Ko GH, Seo HG, Lee JH, Chang KC. Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo. Atherosclerosis. 2011 Jun 30. [Epub ahead of print] PubMed PMID: 21764059.
[2]  Ha YM, Ham SA, Kim YM, Lee YS, Kim HJ, Seo HG, Lee JH, Park MK, Chang KC. β(1)-Adrenergic receptor-mediated HO-1 induction, via PI3K and p38 MAPK, by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice. Biochem Pharmacol. 2011 Jul 5. [Epub ahead of print] PubMed PMID:21763292.
[3]  Woo IS, Jin H, Kang ES, Kim HJ, Lee JH, Chang KC, Park JY, Choi WS, Seo HG. TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis through the stabilization of mitochondrial membrane potential. Cancer Lett. 2011 Jun 24. [Epub ahead of print] PubMed PMID: 21723035.
[4]  Joe Y, Kim HJ, Kim S, Chung J, Ko MS, Lee WH, Chang KC, Park JW, Chung HT. Tristetraprolin Mediates Anti-inflammatory Effects of Nicotine in Lipopolysaccharide-stimulated Macrophages. J Biol Chem. 2011 Jul 15;286(28):24735-42. Epub 2011 May 23. PubMed PMID: 21606497; PubMed Central PMCID: PMC3137049.
[5]  Ok SH, Jeong YS, Kim JG, Lee SM, Sung HJ, Kim HJ, Chang KC, Kwon SC, Sohn JT. C-Jun NH2-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle. Yonsei Med J. 2011 May;52(3):420-8. PubMed PMID: 21488184; PubMed Central PMCID: PMC3101051.
[6]  Kim HJ, Ham SA, Paek KS, Hwang JS, Jung SY, Kim MY, Jin H, Kang ES, Woo IS, Kim HJ, Lee JH, Chang KC, Han CW, Seo HG. Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells. Biochem Biophys Res Commun. 2011 Mar 25;406(4):564-9.
[7]  Kang ES, Iwata K, Ikami K, Ham SA, Kim HJ, Chang KC, Lee JH, Kim JH, Park SB, Kim JH, Yabe-Nishimura C, Seo HG. Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation. Free Radic Biol Med. 2010 Dec 20. [Epub ahead of print] PubMed PMID: 21182935.
[8]  Tsoyi K, Jang HJ, Kim JW, Chang HK, Kim HJ, Pae HO, Seo HG, Lee JH, Lee YS, Chung HT, Chang KC. Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction. Antioxid Redox Signal. 2010 Nov 17. [Epub ahead of print] PubMed PMID: 21083424.
[9]  Jun MS, Ha YM, Kim HS, Jang HJ, Kim YM, Lee YS, Kim HJ, Seo HG, Lee JH, Lee SH, Chang KC. Anti-inflammatory action of methanol extract of Carthamus tinctorius involves in heme oxygenase-1 induction. J Ethnopharmacol. 2010 Oct 20. [Epub ahead of print] PubMed PMID: 20969944.
[10]  Moon L, Jun MS, Kim YM, Lee YS, Kim HJ, Seo HG, Lee JH, Son KH, Lee DH, Kim YS, Park K, Chang KC. 7, 8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ inhuman endothelial cells. Food Chem Toxicol. 2010 Oct 12. [Epub ahead of print] PubMed PMID: 20946932.
[11]  Moon L, Ha YM, Jang HJ, Kim HS, Jun MS, Kim YM, Lee YS, Lee DH, Son KH, Kim HJ, Seo HG, Lee JH, Kim YS, Chang KC. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae Rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: Involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways. J Ethnopharmacol. 2010 Oct 16. [Epub ahead of print] PubMed PMID: 20937376.
[12]  Tsoyi K, Jang HJ, Nizamutdinova IT, Park K, Kim YM, Kim HJ, Seo HG, Lee JH, Chang KC. PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells. Atherosclerosis. 2010 Nov;213(1):115-21. Epub 2010 Aug 19. PubMed PMID: 20864106.
[13]  Konstantin Tsoyi, Hwa Jin Jang, Irina Tsoy Nizamutdinova, Young Min Kim, Young Soo Lee, Hye Jung Kim, Han Geuk Seo, Jae Heun Lee, Ki Churl Chang* Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate in endotoxemic mice British Journal of Pharmacology 2010, accepted
[14]  Tsoyi K, Nizamutdinova IT, Jin Jang H, Mun L, Kim HJ, Seo HG, Lee JH, ChangKC. CARBON MONOXIDE FROM CORM-2 REDUCES HMGB1 RELEASE THROUGH REGULATION OF IFN-beta/JAK-2/STAT-1/INOS/NO SIGNALING BUT NOT COX-2 IN TLR-ACTIVATED MACROPHAGES. Shock. 2010 May 3. [Epub ahead of print] PubMed PMID: 20442692.
[15]  Pae HO, Son Y, Kim NH, Jeong HJ, Chang KC, Chung HT. Role of heme oxygenase in preserving vascular bioactive NO. Nitric Oxide. 2010 Aug 14. [Epub ahead of print] PubMed PMID: 20713168.
[16]  Woo IS, Eun SY, Kim HJ, Kang ES, Kim HJ, Lee JH, Chang KC, Kim JH, Hong SC, Seo HG. Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. Neurosci Lett. 2010 Apr 26;474(2):115-20. Epub 2010 Mar 15. PubMed PMID: 20298756.
[17]  Kim HJ, Kim MY, Hwang JS, Kim HJ, Lee JH, Chang KC, Kim JH, Han CW, Kim JH, Seo HG. PPARdelta inhibits IL-1beta-stimulated proliferation and migration of vascular smooth muscle cells via up-regulation of IL-1Ra. Cell Mol Life Sci. 2010 Jun;67(12):2119-30.
[18]  Lee SA, Kim HJ, Chang KC, Baek JC, Park JK, Shin JK, Choi WJ, Lee JH, Paik WYDHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells. Korean J Physiol Pharmacol. 2009 Aug;13(4):301-
[19]  Nizamutdinova IT, Jin YC, Chung JI, Shin SC, Lee SJ, Seo HG, Lee JH, Chang KC, Kim HJ. The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Mol Nutr Food Res. 2009 Nov;53(11):1419-29.
[20]  Nizamutdinova IT, Kim YM, Chung JI, Shin SC, Jeong YK, Seo HG, Lee JH, Chang KC, Kim HJ. Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells. Food Chem Toxicol. 2009 Nov;47(11):2806-12
[21]  Tsoyi K, Ha YM, Kim YM, Lee YS, Kim HJ, Kim HJ, Seo HG, Lee JH, Chang KC. Activation of PPAR-gamma by Carbon Monoxide from CORM-2 Leads to the Inhibition of iNOS but not COX-2 Expression in LPS-Stimulated Macrophages. Inflammation. 2009 Dec;32(6):364-71.
[22]  Tsoyi K, Kim WS, Kim YM, Kim HJ, Seo HG, Lee JH, Yun-Choi HS, Chang KC. Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells. Atherosclerosis. 2009 Dec;207(2):412-9.
[23]  Ham SA, Kim HJ, Kim HJ, Kang ES, Eun SY, Kim GH, Park MH, Woo IS, Kim HJ, Chang KC, Lee JH, Seo HG. PPARdelta promotes wound healing by upregulating TGF-beta1-dependent or-independent expression of extracellular matrix proteins. J Cell Mol Med. 2009 Jun 16. [Epub ahead of print]
[24]  Nizamutdinova IT, Kim YM, Kim HJ, Seo HG, Lee JH, Chang KC. Carbon monoxide (from CORM-2) inhibits high glucose-induced ICAM-1 expression via AMP-activated protein kinase and PPAR-gamma activations in endothelial cells. Atherosclerosis. 2009 Dec;207(2):405-11.
[25]  Kim YM, Ha YM, Jin YC, Shi LY, Lee YS, Kim HJ, Seo HG, Choi JS, Kim YS, Kang SS, Lee JH, Chang KC. Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat. Food Chem Toxicol. 2009 Aug;47(8):2097-102.
[26]  Kim HJ, Kim MY, Jin H, Kim HJ, Kang SS, Kim HJ, Lee JH, Chang KC, Hwang JY, Yabe-Nishimura C, Kim JH, Seo HG Peroxisome proliferator-activated receptor {delta} regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta}1/Smad3. Circ Res. 2009 Jul 2;105(1):16-24.
[27]  Jin YC, Kim CW, Kim YM, Nizamutdinova IT, Ha YM, Kim HJ, Seo HG, Son KH, Jeon SJ, Kang SS, Kim YS, Kam SC, Lee JH, Chang KC. Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-alpha-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo.Eur J Pharmacol. 2009 Jul 1;614(1-3):91-7
[28]  Tsoyi K, Lee TY, Lee YS, Kim HJ, Seo HG, Lee JH, Chang KC. Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS-and cecal ligation and puncture-induced sepsis model in vivo. Mol Pharmacol. 2009 Jul;76(1):173-82.
[29]  Jeong JJ, Ha YM, Jin YC, Lee EJ, Kim JS, Kim HJ, Seo HG, Lee JH, Kang SS, Kim YS, Chang KC. Rutin from Lonicera japonica inhibits myocardial ischemia/reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro. Food Chem Toxicol. 2009 Jul;47(7):1569-76.
[30]  Nizamutdinova IT, Lee JH, Seo HG, Chang KC, Kim HJ. NS398 protects cells from sodium nitroprusside-mediated cytotoxicity through enhancing HO-1 induction independent of COX-2 inhibition.Arch Pharm Res. 2009 Jan;32(1):99-107.
[31]  Park MK, Kang YJ, Ha YM, Jeong JJ, Kim HJ, Seo HG, Lee JH, Chang KC. EP2 receptor activation by prostaglandin E2 leads to induction of HO-1 via PKA and PI3K pathways in C6 cells. Biochem Biophys Res Commun. 2009 Feb 20;379(4):1043-7.
[32]  Kim JW, Jin YC, Kim YM, Rhie S, Kim HJ, Seo HG, Lee JH, Ha YL, Chang KC. Daidzein administration in vivo reduces myocardial injury in a rat ischemia/reperfusion model by inhibiting NF-kB activation. Life Sci. 2009 Feb 13;84(7-8):227-34.
[33]  Ha YM, Park MK, Kim HJ, Seo HG, Lee JH, Chang KC. High concentrations of ascorbic acid induces apoptosis of human gastric cancer cell by p38-MAP kinase-dependent up-regulation of transferrin receptor. Cancer Lett. 2008 Dec 22. [Epub ahead of print]
[34]  Woo IS, Eun SY, Jang HS, Kang ES, Kim GH, Kim HJ, Lee JH, Chang KC, Kim JH, Han CW, Seo HG. Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death. Cancer Lett. 2009 Apr 8;276(1):53-60.
[35]  Kang ES, Kim GH, Woo IS, Kim HJ, Eun SY, Ham SA, Jin H, Kim MY, Park MH, Kim HJ, Chang KC, Lee JH, Kim JH, Yabe-Nishimura C, Seo HG. Down-regulation of aldose reductase renders J774A.1 cells more susceptible to acrolein-or hydrogen peroxide-induced cell death. Free Radic Res. 2008 Nov;42(11-12):930-8.
[36]  Kim HJ, Sohn JT, Jeong YS, Cho MS, Kim HJ, Chang KC, Shin MK, Park CS, Chung YK. Direct effect of dexmedetomidine on rat isolated aorta involves endothelialnitric oxide synthesis and activation of the lipoxygenase pathway. Clin Exp Pharmacol Physiol. 2008 Oct 31. [Epub ahead of print]PMID
[37]  Jin YC, Kim W, Ha YM, Shin IW, Sohn JT, Kim HJ, Seo HG, Lee JH, Chang KC. Propofol limits rat myocardial ischemia and reperfusion injury with an associated reduction in apoptotic cell death in vivo. Vascul Pharmacol. 2009 Jan-Feb;50(1-2):71-7.
[38]  Park MK, Kang YJ, Lee HS, Kim HJ, Seo HG, Lee JH, Chang KC. The obligatory role of COX-2 expression for induction of HO-1 in ischemic preconditioned rat brain. Biochem Biophys Res Commun. 2008 Dec 26;377(4):1191-4.
[39]  Tsoyi K, Park HB, Kim YM, Chung JI, Shin SC, Shim HJ, Lee WS, Seo HG, Lee JH, Chang KC, Kim HJ. Protective effect of anthocyanins from black soybean seed coats on UVB-induced apoptotic cell death in vitro and in vivo. J Agric Food Chem. 2008 Nov 26;56(22):10600-5.
[40]  Tsoyi K, Park HB, Kim YM, Chung JI, Shin SC, Lee WS, Seo HG, Lee JH, Chang KC, Kim HJ. Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway. J Agric Food Chem. 2008 Oct 8;56(19):8969-74.
[41]  Nizamutdinova IT, Lee GW, Son KH, Jeon SJ, Kang SS, Kim YS, Lee JH, Seo HG, Chang KC, Kim HJ. Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells. Int J Oncol. 2008 Sep;33(3):485-91.
[42]  Woo IS, Jang HS, Eun SY, Kim HJ, Ham SA, Kim HJ, Lee JH, Chang KC, Kim JH, Han CW, Seo HG. Ran suppresses paclitaxel-induced apoptosis in human glioblastoma cells. Apoptosis. 2008 Oct;13(10):1223-31.
[43]  Jin YC, Kim KJ, Kim YM, Ha YM, Kim HJ, Yun UJ, Bae KH, Kim YS, Kang SS, Seo HG, Lee JH, Chang KC. Anti-apoptotic effect of magnolol in myocardial ischemia and reperfusion injury requires extracellular signal-regulated kinase1/2 pathways in rat in vivo. Exp Biol Med (Maywood). 2008 Oct;233(10):1280-8. Jin YC, Gam SC, Jung JH, Hyun JS, Chang KC, Hyun JS. Expression and activity of heme oxygenase-1 in artificially induced low-flow priapism in rat penile tissues. J Sex Med. 2008 Aug;5(8):1876-82.
[44]  Tsoyi K, Kim HJ, Shin JS, Kim DH, Cho HJ, Lee SS, Ahn SK, Yun-Choi HS, Lee JH, Seo HG, Chang KC. HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride. Cell Signal. 2008 Oct;20(10):1839-47
[45]  Sun DI, Nizamutdinova IT, Kim YM, Cai XF, Lee JJ, Kang SS, Kim YS, Kang KM, Chai GY, Chang KC, Kim HJ. Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression. Int Immunopharmacol. 2008 Sep;8(9):1272-81.
[46]  Kang ES, Kim GH, Kim HJ, Woo IS, Ham SA, Jin H, Kim MY, Kim HJ, Lee JH, Chang KC, Seo HG, Hwang JY. Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear factor-kappaB. Pharmacol Res. 2008 Jul;58(1):15-21.
[47]  Nizamutdinova IT, Lee GW, Lee JS, Cho MK, Son KH, Jeon SJ, Kang SS, Kim YS, Lee JH, Seo HG, Chang KC, Kim HJ. Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules. Carcinogenesis. 2008 Oct;29(10):1885-92.
[48]  Eun SY, Woo IS, Jang HS, Jin H, Kim MY, Kim HJ, Lee JH, Chang KC, Kim JH, Seo HG. Identification of cytochrome c oxidase subunit 6A1 as a suppressor of Bax-induced cell death by yeast-based functional screening. Biochem Biophys Res Commun. 2008 Aug 15;373(1):58-63.
[49]  Nizamutdinova IT, Jeong JJ, Xu GH, Lee SH, Kang SS, Kim YS, Chang KC, Kim HJ. Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliate (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells. Int Immunopharmacol. 2008 May;8(5):670-8.
[50]  Pyo MK, Yun-Choi HS, Lee DH, Chang KC. Enantioselective synthesis of r-(+)-and (S)-(-)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation 2008(accepted) J of Medicinal Chemitry Letters
[51]  Nizamutdinova IT, Jin YC, Kim JS, Yean MH, Kang SS, Kim YS, Lee JH, Seo HG, Kim HJ, Chang KC. Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats.Planta Med. 2008 Jan;74(1):14-18.
[52]  Kim HJ, Ham SA, Kim SU, Hwang JY, Kim JH, Chang KC, Yabe-Nishimura C, Kim JH, Seo HG. Transforming growth factor-beta1 is a molecular target for the peroxisome proliferator-activated receptor delta. Circ Res. 2008 Feb 1;102(2):193-200.
[53]  Chae HJ, Kim HR, Kang YJ, Hyun KC, Kim HJ, Seo HG, Lee JH, Yun-Choi HS, Chang KC. Heme oxygenase-1 induction by (S)-enantiomer of YS-51 (YS-51S), a synthetic isoquinoline alkaloid, inhibits nitric oxide production and nuclear factor-kappaB translocation in ROS 17/2.8 cells activated with inflammatory stimulants. Int Immunopharmacol. 2007 Dec 5;7(12):1559-68.
[54]  Heo JM, Kim HJ, Ha YM, Park MK, Kang YJ, Lee YS, Seo HG, Lee JH, Yun-Choi HS, Chang KC. YS 51, 1-(beta-naphtylmethyl)-6, 7-dihydroxy-1, 2, 3, 4,-tetrahydroisoquinoline, protects endothelial cells against hydrogen peroxide-induced injury via carbon monoxide derived from heme oxygenase-1. Biochem Pharmacol. 2007 Nov 1;74(9):1361-70.
[55]  Park MK, Kim CH, Kim YM, Kang YJ, Kim HJ, Kim HJ, Seo HG, Lee JH, Chang KC. Akt-dependent heme oxygenase-1 induction by NS-398 in C6 glial cells: a potential role for CO in prevention of oxidative damage from hypoxia. Neuropharmacology. 2007 Sep;53(4):542-51.
[56]  Kang ES, Woo IS, Kim HJ, Eun SY, Paek KS, Kim HJ, Chang KC, Lee JH, Lee HT, Kim JH, Nishinaka T, Yabe-Nishimura C, Seo HG. Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage. Free Radic Biol Med. 2007 Aug 15;43(4):535-45.
[57]  Kim HJ, Hwang JY, Kim HJ, Choi WS, Lee JH, Kim HJ, Chang KC, Nishinaka T, Yabe-Nishimura C, Seo HG. Expression of a Peroxisome Proliferator-Activated Receptor {gamma}1 Splice Variant that Was Identified in Human Lung Cancers Suppresses Cell Death Induced by Cisplatin and Oxidative Stress. Clin Cancer Res. 2007;13(9):2577-2583.
[58]  Pyo MK, Kim JM, Jin JL, Chang KC, Lee DH, Yun-Choi HS. Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA(2) synthesis and aggregation. Thromb Res. 2007;120(1):81-86.
[59]  Nizamutdinova IT, Oh HM, Min YN, Park SH, Lee MJ, Kim JS, Yean MH, Kang SS, Kim YS, Chang KC, Kim HJ. Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways. Int Immunopharmacol. 2007;7(3):343-350.
[60]  Kim HJ, Tsoyi K, Heo JM, Kang YJ, Park MK, Lee YS, Lee JH, Seo HG, Yun-Choi HS, Chang KC. Regulation of lipopolysaccharide-induced inducible nitric-oxide synthase expression through the nuclear factor-kappaB pathway and interferon-beta/tyrosine kinase 2/Janus tyrosine kinase 2-signal transducer and activator of transcription-1 signaling cascades by 2-naphthylethyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (THI 53), a new synthetic isoquinoline alkaloid. J Pharmacol Exp Ther. 2007;320(2):782-789.
[61]  Kim HJ, Woo IS, Kang ES, Eun SY, Kim GH, Ham SA, Kim HJ, Lee JH, Chang KC, Kim JH, Lee HT, Seo HG. Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARgamma in A549 cells. Biochem Biophys Res Commun. 2006;349(2):660-667.
[62]  Kim HJ, Woo IS, Kang ES, Eun SY, Kim HJ, Lee JH, Chang KC, Kim JH, Seo HG. Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity. Biochem Biophys Res Commun. 2006;347(3):698-706.
[63]  Lee YS, Kang YJ, Kim HJ, Park MK, Seo HG, Lee JH, Yun-Choi HS, Chang KC. Higenamine reduces apoptotic cell death by induction of heme oxygenase-1 in rat myocardial ischemia-reperfusion injury. Apoptosis. 2006;11(7):1091-1100.
[64]  Kim HJ, Tsoy I, Park JM, Chung JI, Shin SC, Chang KC. Anthocyanins from soybean seed coat inhibit the expression of TNF-alpha-induced genes associated with ischemia/reperfusion in endothelial cell by NF-kappaB-dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivo. FEBS Lett. 2006;580(5):1391-1397.
[65]  Kim HJ, Tsoy I, Park MK, Lee YS, Lee JH, Seo HG, Chang KC. Iron released by sodium nitroprusside contributes to heme oxygenase-1 induction via the cAMP-protein kinase A-mitogen-activated protein kinase pathway in RAW 264.7 cells. Mol Pharmacol. 2006;69(5):1633-1640.
[66]  Shin IW, Sohn JT, Park KE, Chang KC, Choi JY, Lee HK, Chung YK. A supraclinical dose of tramadol stereoselectively attenuates endothelium-dependent relaxation in isolated rat aorta. Anesth Analg. 2006;103(2):366-371, .
[67]  Park SE, Sohn JT, Kim C, Chang KC, Shin IW, PaKE, Lee HK, Chung YK. Diazepam attenuates phenylephrine-induced contractions in rat aorta. Anesth Analg. 2006;102(3):682-689.
[68]  Park JE, Kang YJ, Park MK, Lee YS, Kim HJ, Seo HG, Lee JH, Hye Sook YC, Shin JS, Lee HW, Ahn SK, Chang KC. Enantiomers of higenamine inhibit LPS-induced iNOS in a macrophage cell line and improve the survival of mice with experimental endotoxemia. Int Immunopharmacol. 2006;6(2):226-233.
[69]  Oh HM, Kang YJ, Lee YS, Park MK, Kim SH, Kim HJ, Seo HG, Lee JH, Chang KC. Protein kinase G-dependent heme oxygenase-1 induction by Agastache rugosa leaf extract protects RAW264.7 cells from hydrogen peroxide-induced injury. J Ethnopharmacol. 2006;103(2):229-235.

Publications: Conferences/Workshops/Symposiums

[1]  Irina Tosy Nizamutdinova, Kim YM, Chung JI, Shin SC, Lee JH, Seo HG, Chang KC Kim HJ. Anthocyanins inhibit TNF-a-mediated induction of VCAM-1 but not ICAM-1 through the regulation of GATAs and IRF-1, 2008 the 16th federation meeting of Korean basic medical scientists, Seoul, COEX, 2008 5.2
[2]  Irina Tosy Nizamutdinova, Lee GW, Lee JS, Cho MK, Son KH, Jeon SJ, Kang SS, Kim YS, Lee JH, Seo HG, Chang KC Kim HJ. Tanshinone I suppresses growth and invasion of human breast cancer cells through regulation of adhesion molecules, 2008 the 16th federation meeting of Korean basic medical scientists, Seoul, COEX, 2008 5.2
[3]  Konstantin Tsoy, Kim HJ,Kim YM, Jin YC, Lee JH, Seo HG, Chang KC. Inhibitory effect of CKD on the expression of VCAM-1 but not ICAM-1 is through down regulation of Akt and ASTAT-1 activation in LPS-induced HUVECs. 2008 the 16th federation meeting of Korean basic medical scientists, Seoul, COEX, 2008 5.2
[4]  Jeong JJ, Jin YC, Kim JW, Rhie SH, Kim HJ, Lee JH, Seo HG, Chang KC. Rutin protects cardiomyocytes against apoptosis induced by oxidative stress in vitro and in vivo. 2008 the 16th federation meeting of Korean basic medical scientists, Seoul, COEX, 2008 5.2
[5]  Jin YC, Kim JW, Rhie SH, Jeong JJ, Kim HJ,Lee JH, Seo HG, Chang KC. Daidzein reduces myocardial ischemia/reperfusion injury via inhibition of NF-kB activation in rat in vivo. 2008 the 16th federation meeting of Korean basic medical scientists, Seoul, COEX, 2008 5.2
[6]  Jin YC, Kim YM, Ha YM, Kim HJ,Yun UJ, Bae KW, Kim YS, Kang SS, Seo HG, Lee JH, Chang KC. Anti-apoptosis of magnolol in myocardial ischemia and reperfusion injury requires ERK1/2 pathways in rat in vivo. 2008 the 16th federation meeting of Korean basic medical scientists, Seoul, COEX, 2008 5.2
[7]  Chang KC, Nizamutdinova I, Kim HJ, Kim YS, Kang SS. Tanshinone I regulates TNF-a-induced expression of ICAM-1 and VCAM-1 through different mechanisms in HUVECs. Experimental Biology 2008, San Diego, April 5-9
[8]  Jin YC, Kim HJ, Seo HG, Lee JH, Chang KC. Cryptotanshinone attenuates myocardial ischemia/reperfusion injury via anti-inflammatory pathway in rat. The 59th Korean Pharmacological Society Meeting, Jin ju, 2007. 11.1-2
[9]  Jeong JJ, Nizamutdinova I, Choi JY, Lee SH, Kang SS, Kim YS, Kim HJ, Chang KC. Poncirus Trifoliate differentially regulate the expression of adhesion molecules in TNF-a-stimulated HUVECs. The 59th Korean Pharmacological Society Meeting, Jin ju, 2007. 11.1-2
[10]  Konstantin Tsoy, Kim HJ, Sin JS, Kim DH, Cho HJ, Lee SS, Ahn SK, Lee JH, Seo HG, Chang KC. Regulation of lipopolysaccharide-induced nitric oxide synthase and cyclooxygenase-2 production by CKD 712, The 59th Korean Pharmacological Society Meeting, Jin ju, 2007. 11.1-2
[11]  Kang ES, Kim HJ, Kim GH, Ham SA, Kim HJ, Lee JH, Chang KC, Seo HG. Nuclear factor-Woo IS, Eun SY, Kang ES, Kim GH, Kim HJ, Lee JH, Chang KC, Seo HG. RAN has suppressive effect on pacritaxel-induced apoptosis in human glioblast cells. The 59th Korean Pharmacological Society Meeting, Jin ju, 2007. 11.1-2
[12]  Eun SY, Woo IS, Kim HJ, Ham SA, Kim HJ, Lee JH, Chang KC, Seo HG. ADP-ribosylation factor 4, a mammalian apoptosis suppressor identified by yeast-based functional screening The 59th Korean Pharmacological Society Meeting, Jin ju, 2007. 11.1-2
[13]  Irina Tosy Nizamutdinova, Kim YM, Lee JH, Seo HG, Chang KC Kim HJ. Anthocyanins differentially regulate TNF-a-mediated induction of ICAM-1 and VCAM-1 in HUVECs The 59th Korean Pharmacological Society Meeting, Jin ju, 2007. 11.1-2
[14]  Chang KC. Protective effect of ingredients of some herbal medicine against myocardial injury: Seminar on standardization of oriental medicine. Chonan, Sangrok resort, 2007.10-26-27
[15]  Irina Tosy Nizamutdinova, Jeong JJ, Lee JH, Seo HG, Chang KC Kim HJ. Tanshinone I regulates TNF-a-induced expression of ICAM-1 and VCAM-1 through different mechanisms in HUVECs. The 59th Korean Pharmacological Society Meeting, Jin ju, 2007. 11.1-2
[16]  Chang KC. Inhibition of angiontensin II-stimulated vascular smooth muscle cell proliferation via heme oxygenase-1 induction. 2005, July 5. Kor Free Rad. Assoc.
[17]  Cardiovascular Pharmacology of a limited series of tetrahydroisoquinolkine compounds. IUPHAR abstract. 1998 July; 511
[18]  Prevention of the expression of iNOS by a novel positive inotropic agent, YS 49, in rat aorta and RAW 264.7 cells. IUPHAR abstract. 1998 July; 186
[19]  Nitric oxide mediated relaxation may be less sensitive to cytosolic Ca2+ change during membrane depolarization in vascular smooth muscle. ASPET meeting abstract. 1997 July; 332
[20]  Characterization of UV-light induced relaxation in rat aorta. ASPET meeting abstract. 1997 July; 16
[21]  Characterization of UV light induced relaxation in vascular smooth muscle. FASEB meeting. 1996 July; 241
[22]  Effects of GS 386 on isolated rat trachealis and human platelet. FASEB meeting. 1996 July; 319
[23]  Photoinduced adequate nitric oxide (PIANO) mediated relaxation mimics NANC nerve stimulation in the rat gastric fundus. International Congress of pharmacology. 1993 July; 217
[24]  Pharmacological characteristics of NANC-mediated and PIANO-mediated relaxation in isolated rabbit corpus cavernosum. International Congress of pharmacology. 1993 July; 226
[25]  GS389 A possible cGMP-specific phosphodi-esterase inhibitor with Ca2+ antagonistic property. Int.Congress of New Drug Development. 1992 July; 83
[26]  Pharmacological evaluation of GS389in vascular smooth muscle. 6th WPR meeting in Pharmacol. 1991 April; 16
[27]  Further investigation of mechanisms of GS389 A TXA2 antagonistic action in platelet and vascular smooth muscle. Brit. J. Pharmacol. 1994 July; 77
[28]  A PIANO generating system as a useful tool for investigation of NO-mediated response. Brit. J. pharmacol. 1994 July; 116: 34
[29]  Cyclic nucleotides differentially phosphorylations induced by phorbol ester in rat aorta. 1994 July; 261
[30]  Evidence that NO mediates relaxation of bladder compliance. J. Urol. 1994 July; 0(0): 178
[31]  PIANO-mediated relaxation in human and guinea pig gall bladder. Am. Gastroenterol. Assoc. 1993 July; 86
[32]  Expression of cyclooxygenase-2 precedes HO-1 induction in the protective action of preconditioning for the late phase of ischemic injury in rat brain Am. Biophysical Soc. Meeting 2005, Feb. 12-16, Long Beach, CA, USA
[33]  YS 49 inhibits Angiotensin II-stimulated VSMC proliferation by HO-1: importance of CO and c-Jun-terminal protein kinase. Experimental Biology 2005, San Diego, CA, USA April 2-6
[34]  Vasodilatory effect of the component from the root of Cynanchum wilfordi and its action mechanism. Kor. Pharmacognosy. 2000 Dec; 31: 34
[35]  Prevention of expression of iNOS by YS49 in RAW 264.7 cells. Kor Pharmacol. 1998 April; 48
[36]  Inhibitory action of some isoquinoline on iNOS expression in the rat vascular smooth induced by LPS. Kor. Immunol. 1998 April; 6
[37]  Pharmacological characteristics of YS51 and YS55 in alpha and beta-adrenoceptors. Kor Pharmacol. 1997 April; 92
[38]  Biological responses of a inotroso compound that releases nitric oxide upon illunmination. Kor. Smooth Mscle. 1996 April; 21
[39]  Photo-released NO but not NANC nerve stimulation unmasks relaxation in high K+ contracted rabbit corplus cavernosum. Basic Medicine. 1996 April; 31
[40]  Pharmacological characterization of NO-mediated relaxation in 5-HT and K+ contracted rat gastric fundus. Kor. Mol. Bio. 1996 April; 11
[41]  PIANO system and L-arginine-NO-cGMP pathway modulates human uterine contractility. Basic Medicine. 1994 April; 43
[42]  Comparison of NANC-mediated and PIANO-mediated relaxation in rat gastric and rabbit corpus cavernosum. Basic Medicine. 1994 April; 47
[43]  Isoquinoline are they possible Ca2+ blocker. Kor Appl. Pharmacol. 1994 April; 33
[44]  PIANO-mediated relaxation involves cGMP increase in rat detrusor. Basic Medicine. 1994 April; 70
[45]  A TXA2 antagonistic action of GS389 in platelet and vascular smooth muscle. Kor Pharmacol. 1994 April; 62
[46]  Cardiovascular action of a newly synthesized naphtymethyl substituted THQ in vivo and in vitro. Kor Pharmacol. 1994. April; 68
[47]  Biological responses of NO generated from photochemical reaction of nitro containing compounds. Kor Free Radical. 1994 April; 47-50
[48]  Photo-induced nitric oxide generating system in smooth muscle. Basic Medicine 1993 July
[49]  Pharmacological characterization of effects of verapamil and GSa283 on isolated guinea pig and rat trachealis. Basic Medicine. 1993 July; 66
[50]  THI compounds on calcium channel blockers GS283 GS389. New Drug Develop. 1993 April; 8
[51]  NO-and NO2-Carrying molecules potentiate photorelaxation in rat trachea and aorta. Basic Medicine 1993 April; 26
[52]  Endothelial potentiation of relaxation response to ascorbate in rat and guinea pig aorta. Basic Medicine. 1993 April; 33
[53]  Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats. Basic Medicine. 1993 April
[54]  Does L-arginine/NO pathway involve in photorelaxation in rat aorta. Basic Medicine. 1993 April; 22
[55]  Pharmacological evaluation of GS389 on vascular smooth muscle. Basic Medicine. 1993 April; 82
[56]  Different pharmacological characterization of THI analogs on isolated rat heart and aorta. Basic Medicine. 1993 April; 13
[57]  An attempt to new cardiovascular active drug design of THI series based on the SAR study. Basic Medicine. 1993 April; 63
[58]  Chang KC, Sohn DR, Chong WS, Chung SY, Lee YS, Kim SH, Noh HK, Suh JS, Satoko Takizawa, Hideaki Karaki. GS354 and GS389 New type of calcium channel blockers. Korean J. Pharmacol. 1991 April; 27(1): 12

Publications: Books/Book Chapters

[1]  Chang KC. Review. Pathophysiology of nitric oxide. In Emergency Medicine; 1996 256-284, Ed. Kim HH, Koryo Publishers, Korea
[2]  Chang KC, Chapter translation. Antiarrhythmic agents in Principles of Pharmarcology. The pharmacologic basis of drug therapy, 2006; 116-127. E-public, Korea
[3]  Chang KC. Therapeutics: Basic and clinical medicine 1991, Komunsa, Korea
[4]  Kim HJ, Chang KC Protection of anthocyanins on cardiovascular disease In Anthocyanins as Food Factor: Recent Progress in Studies on Bioavailability and Health Promotion Effects, 2008: 117-127 Ed. Tetsuya Konishi and Takashi Ichiyanagi Research Signpost, India
[5]  Kim HJ, Yun-Choi HS, Chang KC. Septic shock and isoquinoline alkaloid. In Research focus on natural products and the body's immune and inflammatory systems. Ed K.Suk, 207-227. NovaScience Publishers, New York, 2007.